An inflammatory memory and angiogenic self-assembling nanofiber hydrogel scaffold seeded with Akkermansia muciniphila to accelerate the healing of diabetic ischemic ulcers
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DOI: 10.1039/c8ra01662c
Abstract: Refractory ulcers are a major challenge in the treatment of a diabetic foot, because of the immunodeficient, ischemic and high-glucose microenvironment. Inflammatory memory peptides, which were extracted from the immune mediator absent in melanoma 2… read more here.
Keywords: hydrogel; diabetic ischemic; ischemic ulcers; muciniphila ... See more keywords
Endothelial Phospholipase Cγ2 Improves Outcomes of Diabetic Ischemic Limb Rescue Following VEGF Therapy.
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DOI: 10.2337/db21-0830
Abstract: Therapeutic VEGF replenishment has met with limited success for the management of critical limb threatening ischemia (CLTI). To improve outcomes of VEGF therapy we applied single-cell RNA sequencing technology to study the endothelial cells of… read more here.
Keywords: vegf therapy; vegf; diabetic ischemic; cell ... See more keywords
Knockdown of NRSF Alleviates Ischemic Brain Injury and Microvasculature Defects in Diabetic MCAO Mice
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DOI: 10.3389/fneur.2022.869220
Abstract: Diabetes is one of the well-established risk factors of stroke and is associated with a poor outcome in patients with stroke. Previous studies have shown that the expression of neuron restrictive silencer factor (NRSF) is… read more here.
Keywords: mcao; brain; diabetic ischemic; brain injury ... See more keywords
Receptor for Advanced Glycation End Product, Organ Crosstalk, and Pathomechanism Targets for Comprehensive Molecular Therapeutics in Diabetic Ischemic Stroke
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DOI: 10.3390/biom12111712
Abstract: Diabetes mellitus, a well-established risk factor for stroke, is related to higher mortality and poorer outcomes following the stroke event. Advanced glycation end products(AGEs), their receptors RAGEs, other ligands, and several other processes contribute to… read more here.
Keywords: diabetic ischemic; glycation end; advanced glycation; stroke ... See more keywords