XBP1 inhibits mesangial cell apoptosis in response to oxidative stress via the PTEN/AKT pathway in diabetic nephropathy
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DOI: 10.1002/2211-5463.12655
Abstract: Diabetic nephropathy (DN) is a complication of diabetes mellitus (DM) that frequently results in renal disease, and is characterized by a variety of symptoms, including albuminuria. It has been shown that apoptosis of glomerular mesangial… read more here.
Keywords: pten akt; apoptosis; oxidative stress; cell apoptosis ... See more keywords
Ombuin ameliorates diabetic nephropathy in rats by anti‐inflammation and antifibrosis involving Notch 1 and PPAR γ signaling pathways
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DOI: 10.1002/ddr.21956
Abstract: Diabetic nephropathy (DN) is a common complication of diabetes and it is urgent to develop effective therapies for DN. In this study, high‐sucrose and high‐fat diet combined with streptozotocin was used to induce DN in… read more here.
Keywords: inflammation; ppar; ombuin ameliorates; ameliorates diabetic ... See more keywords
Therapeutic application of nutraceuticals in diabetic nephropathy: Current evidence and future implications
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DOI: 10.1002/dmrr.3336
Abstract: Diabetes mellitus (DM) is a common metabolic disease which may cause several complications, such as diabetic nephropathy (DN). The routine medical treatments used for DM are not effective enough and have many undesirable side effects.… read more here.
Keywords: nephropathy current; current evidence; nutraceuticals diabetic; diabetic nephropathy ... See more keywords
Ponicidin attenuates streptozotocin‐induced diabetic nephropathy in rats via modulating hyperlipidemia, oxidative stress, and inflammatory markers
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DOI: 10.1002/jbt.22988
Abstract: The present research work was proposed to discover the beneficial roles of ponicidin against the streptozotocin (STZ)‐induced diabetic nephropathy (DN) in rats via modulating the oxidative stress and inflammation. The DN was initiated to the… read more here.
Keywords: stress; ponicidin; oxidative stress; induced diabetic ... See more keywords
Fenofibrate improves renal function by amelioration of NOX‐4, IL‐18, and p53 expression in an experimental model of diabetic nephropathy
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DOI: 10.1002/jcb.27055
Abstract: Among several pathological mechanisms involved in diabetic nephropathy, oxidative stress, inflammation, and apoptosis play a prominent role. Fenofibrate, a peroxisome proliferator‐activated receptor‐α (PPAR‐α) agonist, has markedly improved oxidative stress and inflammatory responses, but there is… read more here.
Keywords: expression; diabetic nephropathy; fenofibrate; renal function ... See more keywords
MiR‐130b increases fibrosis of HMC cells by regulating the TGF‐β1 pathway in diabetic nephropathy
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DOI: 10.1002/jcb.27688
Abstract: Basement membrane thickening, glomerular hypertrophy, and deposition of multiple extracellular matrix characterize the pathological basis of diabetic nephropathy (DN), a condition which ultimately leads to glomerular and renal interstitial fibrosis. Here, we identified a novel… read more here.
Keywords: fibrosis; diabetic nephropathy; hmc cells; 130b increases ... See more keywords
Identification of key biomarkers in diabetic nephropathy via bioinformatic analysis
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DOI: 10.1002/jcb.28155
Abstract: Diabetic nephropathy (DN) is a major cause of end‐stage renal disease. Although intense efforts have been made to elucidate the pathogenesis, the molecular mechanisms of DN remain to be clarified. To identify the candidate genes… read more here.
Keywords: identification key; analysis; hub genes; biomarkers diabetic ... See more keywords
Probiotics ameliorates glycemic control of patients with diabetic nephropathy: A randomized clinical study
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DOI: 10.1002/jcla.23650
Abstract: This research aimed to explore the effects of probiotic administration on glycemic control and renal function in patients with diabetic nephropathy (DN). read more here.
Keywords: patients diabetic; control patients; diabetic nephropathy; glycemic control ... See more keywords
Significance of serum miR‐29a in the occurrence and progression of diabetic nephropathy: A cross‐sectional study
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DOI: 10.1002/jcla.24210
Abstract: Diabetic nephropathy (DN), a common microvascular complication of type 2 diabetes mellitus (T2DM), is an important factor causing chronic kidney disease. However, the relationship between miR‐29a and DN remains unknown. Therefore, a cross‐sectional study was… read more here.
Keywords: cross sectional; diabetic nephropathy; mir 29a; serum mir ... See more keywords
Associations of serum amyloid A and 25‐hydroxyvitamin D with diabetic nephropathy: A cross‐sectional study
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DOI: 10.1002/jcla.24283
Abstract: The present study investigated the relationships between serum amyloid A (SAA), 25‐hydroxyvitamin D (25(OH)VD) and diabetic nephropathy (DN) to provide evidence for the prevention and management of DN. read more here.
Keywords: serum amyloid; hydroxyvitamin diabetic; diabetic nephropathy; study ... See more keywords
Anti‐inflammatory effects of resolvins in diabetic nephropathy: Mechanistic pathways
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DOI: 10.1002/jcp.28315
Abstract: The incidence of diabetes mellitus is growing rapidly. The exact pathophysiology of diabetes is unclear, but there is increasing evidence of the role of the inflammatory response in both developing diabetes as well as its… read more here.
Keywords: anti inflammatory; resolvins diabetic; effects resolvins; diabetic nephropathy ... See more keywords