Diabetic neuropathic cachexia with profound autonomic dysfunction in a young female with type 1 diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Acta Diabetologica"
DOI: 10.1007/s00592-017-1017-7
Abstract: Although peripheral neuropathy is a common complication of diabetes mellitus, its variant—diabetic neuropathic cachexia (DNC)—is extremely rare. It refers to a specific neuro-endocrine disorder characterized by an acute or subacute onset of intense neuropathic pains,… read more here.
Keywords: neuropathic cachexia; type diabetes; diabetic neuropathic; profound autonomic ... See more keywords
Erratum to: The effect of sinomenine in diabetic neuropathic pain mediated by the P2X3 receptor in dorsal root ganglia
Sign Up to like & getrecommendations! Published in 2017 at "Purinergic Signalling"
DOI: 10.1007/s11302-017-9560-9
Abstract: Type 2 diabetes mellitus (T2DM) accounts for more than 90% of all cases of diabetes mellitus (DM). Diabetic neuropathic pain (DNP) is a common complication of T2DM. Sinomenine is a natural bioactive component extracted from… read more here.
Keywords: t2dm; sinomenine; diabetic neuropathic; p2x3 receptor ... See more keywords
Inhibition of protein tyrosine phosphatase 1B in spinal cord dorsal horn of rats attenuated diabetic neuropathic pain
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.03.012
Abstract: Abstract Protein tyrosine phosphatase 1B (PTP1B) has been shown to dephosphorylate and inactivate insulin receptors, which contributes to the pathogenesis of diabetes. Neuropathic pain is one of the severe complications that results from diabetic neuropathy.… read more here.
Keywords: cord dorsal; dorsal horn; diabetic neuropathic; neuropathic pain ... See more keywords
Serum brain-derived neurotrophic factor levels in patients with diabetic neuropathic pain
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135655
Abstract: OBJECTIVE Diabetic neuropathic pain (DNP) is one of the most common and severe complications in patients with diabetes. This study aimed to investigate serum brain-derived neurotrophic factor (BDNF) levels in patients with DNP and to… read more here.
Keywords: dnp; diabetic neuropathic; serum brain; neuropathic pain ... See more keywords
Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.01.049
Abstract: Long noncoding RNAs (lncRNAs) participate in a diverse range of molecular and biological processes, and dysregulation of lncRNAs has been observed in the pathogenesis of various human diseases. We observed alterations in mechanical withdrawal thresholds… read more here.
Keywords: mediated diabetic; diabetic neuropathic; neuropathic pain; trpv1 mediated ... See more keywords
Salidroside alleviates diabetic neuropathic pain through regulation of the AMPK-NLRP3 inflammasome axis.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2021.115468
Abstract: High glucose (HG)-induced nucleotide-binding and oligomerization (NACHT) domain, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3 (NLRP3) inflammasome activation leads to diabetic neuropathic pain. We recently showed that salidroside could suppress NLRP3 inflammasome activation… read more here.
Keywords: ampk nlrp3; inflammasome axis; diabetic neuropathic; neuropathic pain ... See more keywords
Exploring the Potent Combination of Quercetin-Boronic Acid, Epalrestat, and Urea Containing Nanoethosomal Keratolytic Gel for the Treatment of Diabetic Neuropathic Pain: In Vitro and In Vivo Studies.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00236
Abstract: Transdermal penetration of therapeutic moieties from topical dosage forms always remains a challenge due to the presence of permeation impeding keratin which should be addressed. The purpose of the study was to formulate quercetin and… read more here.
Keywords: diabetic neuropathic; boronic acid; gel; pain ... See more keywords
First-in-human phase I studies of YJ001 spray applied to local skin in healthy subjects and patients with diabetic neuropathic pain.
Sign Up to like & getrecommendations! Published in 2023 at "Expert opinion on investigational drugs"
DOI: 10.1080/13543784.2023.2219388
Abstract: BACKGROUND The study aimed to investigate the safety, pharmacokinetics (PK), and efficacy of YJ001 spray, a candidate drug for diabetic neuropathic pain (DNP) therapy. RESEARCH DESIGN & METHODS Forty-two healthy subjects received one of four… read more here.
Keywords: spray; diabetic neuropathic; neuropathic pain; yj001 spray ... See more keywords
Dose-response Relationship of Photobiomodulation Therapy on Matrix Metalloproteinase in Healing Dynamics of Diabetic Neuropathic Ulcers- An in Vivo Study.
Sign Up to like & getrecommendations! Published in 2022 at "Photochemistry and photobiology"
DOI: 10.1111/php.13754
Abstract: Individuals with diabetic foot ulcers have overlapped the inflammatory, proliferative, and remodeling phase, making the tissue vulnerable to delayed healing responses. We aimed to establish the dose-response relationship of photobiomodulation therapy of different doses and… read more here.
Keywords: dose response; photobiomodulation therapy; therapy; diabetic neuropathic ... See more keywords
HIF-1α Ameliorates Diabetic Neuropathic Pain via Parkin-Mediated Mitophagy in a Mouse Model
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/5274375
Abstract: Mitochondrial dysfunction, which can be regulated by mitophagy, plays a central role in diabetic neuropathic pain (DNP). Mitophagy that was involved in nerve damage-induced neuropathic pain has been reported. Hyperglycemia and cellular hypoxic were the… read more here.
Keywords: dnp; diabetic neuropathic; hif; mitophagy ... See more keywords
Effect of Riluzole on the Expression of HCN2 in Dorsal Root Ganglion Neurons of Diabetic Neuropathic Pain Rats
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Healthcare Engineering"
DOI: 10.1155/2022/8313415
Abstract: Neuropathic pain since early diabetes swamps patients' lives, and diabetes mellitus has become an increasingly worldwide epidemic. No agent, so far, can terminate the ongoing diabetes. Therefore, strategies that delay the process and the further… read more here.
Keywords: diabetic neuropathic; effect riluzole; root ganglion; neuropathic pain ... See more keywords