Genetics of diabetic neuropathy: Systematic review, meta‐analysis and trial sequential analysis
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DOI: 10.1002/acn3.50892
Abstract: Diabetic neuropathy (DN) is one of the most common complications of diabetes that occurs in more than 67% of individuals with diabetes. Genetic polymorphisms may play an important role in DN development. However, until now,… read more here.
Keywords: review meta; diabetic neuropathy; analysis; systematic review ... See more keywords
Serum lipidomic determinants of human diabetic neuropathy in type 2 diabetes
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DOI: 10.1002/acn3.51639
Abstract: The serum lipidomic profile associated with neuropathy in type 2 diabetes is not well understood. Obesity and dyslipidemia are known neuropathy risk factors, suggesting lipid profiles early during type 2 diabetes may identify individuals who… read more here.
Keywords: serum lipidomic; neuropathy type; diabetic neuropathy; type diabetes ... See more keywords
Anxiety affects disability and quality of life in patients with painful diabetic neuropathy
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DOI: 10.1002/ejp.1067
Abstract: Painful diabetic neuropathy (PDN) is known to negatively affect psychosocial functioning as expressed by enhanced levels of anxiety and depression. The aim of this study was to specify diabetes and pain‐related fears. read more here.
Keywords: disability quality; painful diabetic; diabetic neuropathy; affects disability ... See more keywords
Histone deacetylase 5‐induced deficiency of signal transducer and activator of transcription‐3 acetylation contributes to spinal astrocytes degeneration in painful diabetic neuropathy
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DOI: 10.1002/glia.24328
Abstract: Diabetes patients with painful diabetic neuropathy (PDN) show severe spinal atrophy, suggesting pathological changes of the spinal cord contributes to central sensitization. However, the cellular changes and underlying molecular mechanisms within the diabetic spinal cord… read more here.
Keywords: diabetic neuropathy; spinal astrocytes; signal transducer; painful diabetic ... See more keywords
Nebivolol, a β-blocker abrogates streptozotocin-induced behavioral, biochemical, and neurophysiological deficit by attenuating oxidative-nitrosative stress: a possible target for the prevention of diabetic neuropathy
Sign Up to like & getrecommendations! Published in 2017 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-017-1450-8
Abstract: Metabolic abnormalities including hyperglycemia, hyperlipidemia, and oxidative-nitrosative stress are involved in the progression of diabetic neuropathy. In the present study, we targeted oxidative-nitrosative stress using nebivolol, a β1-receptor antagonist with vasodilator and antioxidant property, to… read more here.
Keywords: streptozotocin induced; nebivolol; diabetic neuropathy; oxidative nitrosative ... See more keywords
Toll-Like Receptor 2 Antagonist Ameliorates Type 2 Diabetes Mellitus Associated Neuropathic Pain by Repolarizing Pro-inflammatory Macrophages.
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DOI: 10.1007/s11064-021-03365-3
Abstract: Diabetic neuropathy is one of the common complications of type 2 diabetes mellitus (T2DM) with severe outcomes. The mechanisms of physiopathology of diabetic neuropathy are not well elucidated. Inflammation and inflammatory macrophages are recognized to… read more here.
Keywords: inflammatory macrophages; t2dm mice; pro inflammatory; diabetic neuropathy ... See more keywords
Neuromodulation Interventions for the Treatment of Painful Diabetic Neuropathy: a Systematic Review
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DOI: 10.1007/s11916-022-01035-9
Abstract: Painful diabetic neuropathy (PDN) is a prevalent and debilitating condition, characterized by severe burning, tingling, and lancinating pain usually located in the distal lower extremities. In addition to manifesting with severe pain, PDN may also… read more here.
Keywords: interventions treatment; neuromodulation interventions; diabetic neuropathy; treatment ... See more keywords
Role of miRNAs in diabetic neuropathy: mechanisms and possible interventions.
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DOI: 10.1007/s12035-021-02662-w
Abstract: Accelerating cases of diabetes worldwide have given rise to higher incidences of diabetic complications. MiRNAs, a much-explored class of non-coding RNAs, play a significant role in the pathogenesis of diabetes mellitus by affecting insulin release,… read more here.
Keywords: signaling pathways; diabetic foot; mir; diabetic neuropathy ... See more keywords
Diabetic Neuropathy Collection: Treatment of Diabetic Neuropathy
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DOI: 10.1007/s13300-020-00784-3
Abstract: Video: Treatment of Diabetic Neuropathy podcast recording (MP4 61908 kb) read more here.
Keywords: neuropathy collection; treatment diabetic; diabetic neuropathy; collection treatment ... See more keywords
A Consideration of the Psychological Aspects to Managing Patients with Painful Diabetic Neuropathy: An Insight into Pain Management Services at a Tertiary Centre in the UK
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DOI: 10.1007/s13300-020-00983-y
Abstract: Painful diabetic neuropathy (pDN) is characterised by both sensory and affective disturbances, suggesting a complex bidirectional relationship of neuropathic pain and mood disorders. Data on pDN indicate that neuropathic pain reduces quality of life, including… read more here.
Keywords: painful diabetic; diabetic neuropathy; pain management; management ... See more keywords
Treating Pain in Diabetic Neuropathy: Current and Developmental Drugs
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DOI: 10.1007/s40265-020-01259-2
Abstract: There is a high prevalence of painful diabetic polyneuropathy (pDPN) with around one-third of all patients with diabetes suffering from pDPN. pDPN has debilitating consequences, with a major impact on morbidity and quality of life.… read more here.
Keywords: treating pain; pdpn; diabetic neuropathy; drugs treating ... See more keywords