Podocyte-specific chemokine (C-C motif) receptor 2 overexpression mediates diabetic renal injury in mice.
Sign Up to like & getrecommendations! Published in 2017 at "Kidney international"
DOI: 10.1016/j.kint.2016.09.042
Abstract: Inflammation is a central pathophysiologic mechanism that contributes to diabetes mellitus and diabetic nephropathy. Recently, we showed that macrophages directly contribute to diabetic renal injury and that pharmacological blockade or genetic deficiency of chemokine (C-C… read more here.
Keywords: chemokine motif; ccr2; renal injury; diabetic nephropathy ... See more keywords
Connexin 43 prevents the progression of diabetic renal tubulointerstitial fibrosis by regulating the SIRT1-HIF-1α signaling pathway.
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DOI: 10.1042/cs20200171
Abstract: Hyperglycemia-induced renal epithelial to mesenchymal transition (EMT) is a key pathological factor in diabetic renal tubulointerstitial fibrosis (RIF). Our previous studies have shown that connexin 43 (Cx43) activation attenuated the development of diabetic renal fibrosis.… read more here.
Keywords: hif; renal tubulointerstitial; diabetic renal; tubulointerstitial fibrosis ... See more keywords
Role of Retrograde Intrarenal Surgery in the Management of Diabetic Renal Papillary Necrosis.
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DOI: 10.1089/end.2022.0175
Abstract: INTRODUCTION Diabetic renal papillary necrosis (RPN) is challenging to diagnose radiologically due to the limitation in performing a contrast study in patients with compromised renal function. Endoscopic management by double 'J' (DJ) stenting or percutaneous… read more here.
Keywords: diabetic renal; renal papillary; role; management ... See more keywords
Non‐diabetic renal disease in patients with type 2 diabetes: a single centre study
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DOI: 10.1111/imj.13708
Abstract: Non‐diabetic renal disease (NDRD) has been widely known in diabetic patients. The clinical differentiation between diabetic nephropathy (DN) and NDRD is still not so clear and effective. read more here.
Keywords: patients type; disease patients; renal disease; non diabetic ... See more keywords
Tolvaptan alleviates excessive fluid retention of nephrotic diabetic renal failure unresponsive to furosemide.
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DOI: 10.1111/nep.13286
Abstract: Patients with diabetic nephropathy develop nephrotic syndrome, and may show limited response to conventional therapy. They often require earlier initiation of renal replacement therapy because they become refractory to diuretics, and experience excessive fluid retention.… read more here.
Keywords: failure; diabetic renal; excessive fluid; fluid retention ... See more keywords
Protective Effects of Adiponectin Against Diabetic Renal Injury in a Mouse Model of Diabetes
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DOI: 10.1159/000481612
Abstract: Background/Aims: Adiponectin (Apn) has shown anti-diabetic and anti-inflammatory potential. In the study, we studied and tested the protective effects of Apn against diabetic renal injury and the possible mechanism of these effects. Methods: After 1… read more here.
Keywords: group; model; group apn; renal injury ... See more keywords
Formononetin Activates the Nrf2/ARE Signaling Pathway Via Sirt1 to Improve Diabetic Renal Fibrosis
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DOI: 10.3389/fphar.2020.616378
Abstract: Oxidative stress is the main factor responsible for the induction of diabetic renal fibrosis. Thus, improving the state of oxidative stress can effectively prevent the further deterioration of diabetic nephropathy (DN). Previous research has shown… read more here.
Keywords: sirt1; nrf2 signaling; signaling pathway; renal fibrosis ... See more keywords