POSTN promotes diabetic vascular calcification by interfering with autophagic flux.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2021.109983
Abstract: Autophagy is a lysosomal degradative process that is closely related to the pathogenesis of vascular calcification. Recent evidence suggests that periostin (POSTN) is a unique extracellular matrix protein that is associated with diabetic vascular complications.… read more here.
Keywords: diabetic vascular; vascular calcification; postn; calcification ... See more keywords
Noncoding RNAs involved in DNA Methylation and Histone methylation, and acetylation in Diabetic Vascular Complications.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2021.105520
Abstract: Diabetes is a metabolic disorder and its incidence is still increasing. Diabetic vascular complications cause major diabetic mobility and include accelerated atherosclerosis, nephropathy, retinopathy, and neuropathy. Hyperglycemia contributes to the pathogenesis of diabetic vascular complications… read more here.
Keywords: methylation; diabetic vascular; histone methylation; vascular complications ... See more keywords
CIDEC: A Potential Factor in Diabetic Vascular Inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Vascular Research"
DOI: 10.1159/000520685
Abstract: Cell death-inducing DFF45-like effector C (CIDEC) is involved in diet-induced adipose inflammation. Whether CIDEC plays a role in diabetic vascular inflammation remains unclear. A type 2 diabetic rat model was induced by high-fat diet and… read more here.
Keywords: inflammation; diabetic vascular; vascular inflammation; cidec ... See more keywords
Associations of Obesity Indices with Bone Mineral Densities and Risk of Osteoporosis Stratified Across Diabetic Vascular Disease in T2DM Patients
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"
DOI: 10.2147/dmso.s384266
Abstract: Objective To evaluate associations of obesity indices with bone mineral densities (BMD) and risk of osteoporosis in T2DM patients totally and stratified across presence of any diabetic cardiovascular complications. Methods Cross-sectional analyses of baseline information… read more here.
Keywords: diabetic vascular; t2dm patients; risk osteoporosis; obesity indices ... See more keywords
Epigenetic Mechanisms in Diabetic Vascular Complications and Metabolic Memory: The 2020 Edwin Bierman Award Lecture
Sign Up to like & getrecommendations! Published in 2021 at "Diabetes"
DOI: 10.2337/dbi20-0030
Abstract: Macrovascular complications such as atherosclerosis, myocardial infarction and stroke, and microvascular complications such as nephropathy, retinopathy, and neuropathy are the major causes of increased morbidity and mortality in both type 1 and type 2 diabetes.… read more here.
Keywords: diabetic vascular; metabolic memory; complications metabolic; epigenetic mechanisms ... See more keywords
Exosomes: Biomarkers and Therapeutic Targets of Diabetic Vascular Complications
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.720466
Abstract: Diabetic vascular complications (DVC) including macrovascular and microvascular lesions, have a significant impact on public health, and lead to increased patient mortality. Disordered intercellular cascades play a vital role in diabetic systemic vasculopathy. Exosomes participate… read more here.
Keywords: exosomes biomarkers; diabetic vascular; targets diabetic; therapeutic targets ... See more keywords
Dicarbonyl Stress in Diabetic Vascular Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23116186
Abstract: Late vascular complications play a prominent role in the diabetes-induced increase in morbidity and mortality. Diabetes mellitus is recognised as a risk factor driving atherosclerosis and cardiovascular mortality; even after the normalisation of blood glucose… read more here.
Keywords: diabetic vascular; vascular complications; mgo; dicarbonyl stress ... See more keywords
Profiling of Differentially Expressed MicroRNAs in Human Umbilical Vein Endothelial Cells Exposed to Hyperglycemia via RNA Sequencing
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13061296
Abstract: Hyperglycemia is the hallmark of diabetes mellitus that results in oxidative stress, apoptosis, and diabetic vascular endothelial dysfunction. An increasing number of microRNAs (miRNAs) have been found to be involved in the pathogenesis of diabetic… read more here.
Keywords: diabetic vascular; cells exposed; endothelial cells; differentially expressed ... See more keywords
The Attenuating Effect of Beta-Carotene on Streptozotocin Induced Diabetic Vascular Dementia Symptoms in Rats
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27134293
Abstract: This study investigated the ameliorative effects of beta-carotene (BC) on diabetes-associated vascular dementia and its action against biomolecule oxidation. The diabetic vascular dementia (VaD) was induced by administration of nicotinamide (NA; 50 mg/kg; i.p.) and… read more here.
Keywords: vascular dementia; diabetic vascular; beta carotene; attenuating effect ... See more keywords
Vaccinium as Potential Therapy for Diabetes and Microvascular Complications
Sign Up to like & getrecommendations! Published in 2023 at "Nutrients"
DOI: 10.3390/nu15092031
Abstract: Diabetes mellitus is one of the most critical global health concerns, with a fast-growing prevalence. The incidence of diabetic vascular complications is also rapidly increasing, exacerbating the burden on individuals with diabetes and the consumption… read more here.
Keywords: potential therapy; diabetic vascular; microvascular complications; vascular complications ... See more keywords