Diacerein ameliorates acetaminophen hepatotoxicity in rats via inhibiting HMGB1/TLR4/NF-κB and upregulating PPAR-γ signal.
Sign Up to like & getrecommendations! Published in 2022 at "Molecular biology reports"
DOI: 10.1007/s11033-022-07366-5
Abstract: BACKGROUND Acetaminophen (APAP) is a worldwide antipyretic as well as an analgesic medication. It has been extensively utilized during the outbreak of coronavirus 2019 (COVID-19). APAP misuse would lead to liver injury. Diacerein (DIA), an… read more here.
Keywords: tlr4; expression; liver injury; diacerein ... See more keywords
Interleukin-6 expression and its modulation by diacerein in a rat model of chronic stress induced cardiac dysfunction
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e08522
Abstract: People with chronic stress have higher levels of pro-inflammatory cytokines, which enhance their susceptibility to cardiovascular diseases. Diacerein has ability to modulate pro-inflammatory cytokines such as IL-1β and IL-6; however, its efficacy in chronic stress… read more here.
Keywords: stress; model chronic; rat model; stress induced ... See more keywords
Diacerein ameliorates kidney injury induced by cisplatin in rats by activation of Nrf2/Ho-1 pathway and Bax down-regulation
Sign Up to like & getrecommendations! Published in 2021 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2021.08.025
Abstract: Abstract Cisplatin is an antineoplastic medicine used for solid tumor treatment. The main side effect that limits its dose is nephrotoxicity. Diacerein has been used for the treatment of joint diseases like osteoarthritis. It also… read more here.
Keywords: bax; induced cisplatin; cisplatin rats; cisplatin ... See more keywords
Development of a Novel Self-Dissolving Microneedle-Assisted Percutaneous Delivery System of Diacerein through Solid Dispersion Gel: Solubility Enhancement, Proof of Anti-inflammatory Activity and Safety.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug delivery"
DOI: 10.2174/1567201819666220629123058
Abstract: BACKGROUND Diacerein, an osteoarthiritis drug, experiences slow topical permeation due to limited solubility. Additionally it shows laxative effect due to acid/base hydrolysis of drug in colon. OBJECTIVE Diacerein solubility was improved to increase percutaneous drug… read more here.
Keywords: dissolving microneedle; solid dispersion; diacerein; solubility ... See more keywords
Topical Diacerein Decreases Skin and Splenic CD11c+ Dendritic Cells in Psoriasis
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054324
Abstract: Psoriasis is an inflammatory skin disease characterized by increased neo-vascularization, keratinocyte hyperproliferation, a pro-inflammatory cytokine milieu and immune cell infiltration. Diacerein is an anti-inflammatory drug, modulating immune cell functions, including expression and production of cytokines,… read more here.
Keywords: topical diacerein; diacerein; cd11c dendritic; dendritic cells ... See more keywords
Possible Beneficial Role of Novel Anti-Osteoarthritic Drug Diacerein in Rheumatoid Arthritis
Sign Up to like & getrecommendations! Published in 2022 at "Research Journal of Pharmacy and Technology"
DOI: 10.52711/0974-360x.2022.00454
Abstract: A network of proinflammatory cytokines plays an important role in the pathogenesis of osteoarthritis and rheumatoid arthritis. Among these pro-inflammatory cytokines, IL-1 superfamily cytokines like IL-1α, IL-1β, IL-18, IL-33, IL-36 (α, β, γ) play a… read more here.
Keywords: diacerein; role; novel anti; rheumatoid arthritis ... See more keywords
Stability Indicating RP-HPLC-PDA Method for Simultameous Quantification of Glucosamine, Methyl Sulphonyl Methane and Diacerein Tablets
Sign Up to like & getrecommendations! Published in 2019 at "Research Journal of Pharmacy and Technology"
DOI: 10.5958/0974-360x.2019.00020.9
Abstract: A simple, fast, accurate and specific RP-HPLC-PDA method has been developed for the simultaneous quantification of, glucosamine, diacerein and methyl sulphonyl methane and in bulk and tablet dosage form. The chromatographic separation was performed on… read more here.
Keywords: diacerein; methyl; sulphonyl methane; methane ... See more keywords