Access to α,γ-Diamino Diacid Derivatives via Organocatalytic Asymmetric 1,4-Addition of Azlactones and Dehydroalanines.
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DOI: 10.1021/acs.orglett.8b03020
Abstract: A convenient and functional-group-tolerant organocatalytic asymmetric 1,4-addition of azlactones and dehydroalanine is disclosed. The reaction is used for the first synthesis of chiral α,γ-diamino diacid derivatives with nonadjacent stereogenic centers in moderate to high yields,… read more here.
Keywords: diamino diacid; diacid derivatives; organocatalytic asymmetric; addition ... See more keywords