A Fluorescence-Based Assay for Quantitative Analysis of Phospholipid:Diacylglycerol Acyltransferase Activity.
Sign Up to like & getrecommendations! Published in 2019 at "Lipids"
DOI: 10.1002/lipd.12190
Abstract: Phospholipid:diacylglycerol acyltransferase (PDAT) catalyzes the acyl-CoA-independent triacylglycerol (TAG) biosynthesis in plants and oleaginous microorganisms and thus is a key target in lipid research. The conventional in vitro PDAT activity assay involves the use of radiolabeled… read more here.
Keywords: phospholipid diacylglycerol; fluorescence based; diacylglycerol; diacylglycerol acyltransferase ... See more keywords
A yeast‐based tool for screening mammalian diacylglycerol acyltransferase inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "MicrobiologyOpen"
DOI: 10.1002/mbo3.1334
Abstract: Dysregulation of lipid metabolism is associated with obesity and metabolic diseases but there is also increasing evidence of a relationship between lipid body excess and cancer. Lipid body synthesis requires diacylglycerol acyltransferases (DGATs) which catalyze… read more here.
Keywords: yeast based; diacylglycerol; based tool; screening mammalian ... See more keywords
Influence of lard-based diacylglycerol on rheological and physicochemical properties of thermally induced gels of porcine myofibrillar protein at different NaCl concentrations.
Sign Up to like & getrecommendations! Published in 2020 at "Food research international"
DOI: 10.1016/j.foodres.2019.108723
Abstract: This study investigated the role of lard-based diacylglycerol (DG) on the rheological and physicochemical properties of pork myofibrillar protein (MP) gels at different NaCl concentrations. Incorporated unpurified diacylglycerol (UDG) or purified diacylglycerol (PDG) and increased… read more here.
Keywords: lard based; based diacylglycerol; physicochemical properties; diacylglycerol ... See more keywords
Genome-wide analysis and functional characterization of Acyl-CoA:diacylglycerol acyltransferase from soybean identify GmDGAT1A and 1B roles in oil synthesis in Arabidopsis seeds.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of plant physiology"
DOI: 10.1016/j.jplph.2019.153019
Abstract: Acyl-CoA:diacylglycerol acyltransferase (DGAT) is a key enzyme in the Kennedy pathway of triacylglycerol (TAG) synthesis. It catalyzes the acyl-CoA-dependent acylation of sn-1, 2-diacylglycerol to form TAG. DGATs in soybean (Glycine max) have been reported, but… read more here.
Keywords: seed; diacylglycerol; acyl coa; gmdgat1a ... See more keywords
Diacylglycerol lipase alpha promotes tumorigenesis in oral cancer by cell‐cycle progression
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.03.041
Abstract: ABSTRACT Diacylglycerol lipase alpha (DAGLA), which catalyzes the hydrolysis of diacylglycerol to 2‐arachidonoylglycerol and free fatty acid, is required for axonal growth during the brain development and for retrograde synaptic signaling at mature synapses. So… read more here.
Keywords: cell cycle; diacylglycerol; dagla; lipase ... See more keywords
Characterization of Type-2 Diacylglycerol Acyltransferases in the Green Microalga Chromochloris zofingiensis.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.8b05755
Abstract: Diacylglycerol acyltransferase (DGAT) catalyzes the last and committed step of the acyl-CoA-dependent TAG biosynthesis and thus is a key target for manipulating oil production in microalgae. The microalga Chromochloris zofingiensis can accumulate substantial amounts of… read more here.
Keywords: chromochloris zofingiensis; microalga chromochloris; zofingiensis; diacylglycerol ... See more keywords
α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.8b00661
Abstract: Diacylglycerol-lactones have proven to be a powerful template for the design of potent ligands targeting C1 domains, the recognition motif for the cellular second messenger diacylglycerol. A major objective has been to better understand the… read more here.
Keywords: diacylglycerol lactones; selectivity relative; diacylglycerol; fold selectivity ... See more keywords
Diacylglycerol Acyltransferase 1 Is Regulated by Its N-Terminal Domain in Response to Allosteric Effectors1[OPEN]
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DOI: 10.1104/pp.17.00934
Abstract: The N-terminal domain of Brassica diacylglycerol acyltransferase1 binds CoA and acyl-CoA, contributing to feedback inhibition and activation, respectively, of triacylglycerol biosynthesis. Diacylglycerol acyltransferase 1 (DGAT1) is an integral membrane enzyme catalyzing the final and committed… read more here.
Keywords: terminal domain; diacylglycerol; acyl coa; coa ... See more keywords
Inhibition of diacylglycerol kinase alpha to augment antitumor effector T cells in tumor-bearing host.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.4_suppl.293
Abstract: 293 Background: Diacylglycerol kinases (DGKs), lipid kinases transforming diacylglycerol to phosphatidic acid, play important roles in intracellular signal transduction. Diacylglycerol kinase alpha (DGKa), an isozyme of DGKs, is well-known to promote proliferation of cancer cells… read more here.
Keywords: tumor bearing; cd8 cells; tumor; dgka ... See more keywords
Diacylglycerol Kinase ε in Adipose Tissues: A Crosstalk Between Signal Transduction and Energy Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2022.815085
Abstract: Diacylglycerol (DG) is unique in lipid metabolism because it serves not only as an intermediate product for triglyceride synthesis, but also as a signaling molecule that activates proteins containing DG-responsive elements, such as protein kinase… read more here.
Keywords: dgk; energy metabolism; kinase; metabolism ... See more keywords
Variant Amino Acid Residues Alter the Enzyme Activity of Peanut Type 2 Diacylglycerol Acyltransferases
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2017.01751
Abstract: Diacylglycerol acyltransferase (DGAT) catalyzes the final step in triacylglycerol (TAG) biosynthesis via the acyl-CoA-dependent acylation of diacylglycerol. This reaction is a major control point in the Kennedy pathway for biosynthesis of TAG, which is the… read more here.
Keywords: amino acid; enzyme activity; diacylglycerol; peanut ... See more keywords