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Published in 2019 at "Lipids"
DOI: 10.1002/lipd.12190
Abstract: Phospholipid:diacylglycerol acyltransferase (PDAT) catalyzes the acyl-CoA-independent triacylglycerol (TAG) biosynthesis in plants and oleaginous microorganisms and thus is a key target in lipid research. The conventional in vitro PDAT activity assay involves the use of radiolabeled…
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Keywords:
phospholipid diacylglycerol;
fluorescence based;
diacylglycerol;
diacylglycerol acyltransferase ... See more keywords
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Published in 2021 at "Phytochemistry Letters"
DOI: 10.1016/j.phytol.2021.06.013
Abstract: Abstract Three new flavonoids, including a new prenylated aurone, 7,2′,5′-trihydroxy-8-prenylaurone (1), and two new flavanones, 2(S)-4′-hydroxy-6-methoxy-7-(2”-hydroxy-3”-methybult-3”-enyl)flavanone (2) and 2(S)-4′-hydroxy-7-methoxy-6-(1”,2”-epoxy-3”-hydroxy-dimethyl)flavanone (3), together with eight known flavonoids were isolated from the seeds of Psoralea corylifolia L. The…
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Keywords:
inhibit diacylglycerol;
psoralea corylifolia;
seeds psoralea;
corylifolia inhibit ... See more keywords
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Published in 2021 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c04312
Abstract: The primary goal of high-throughput screening (HTS) is to rapidly survey a broad collection of compounds, numbering from tens of thousands to millions of members, and identify those that modulate the activity of a therapeutic…
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Keywords:
high throughput;
ade opi;
diacylglycerol acyltransferase;
phase separated ... See more keywords
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Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c03489
Abstract: Diacylglycerol acyltransferase (DGAT) catalyzes the binding of acyl-CoA to diacylglycerol to form triacylglycerol (TAG). Previous studies strongly indicate that DGAT2, rather than DGAT1, is crucial for TAG accumulation in the oleaginous fungus Mucor circinelloides. To…
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Keywords:
oleaginous fungus;
accumulation;
diacylglycerol acyltransferase;
fermentation ... See more keywords
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Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34339-1
Abstract: Proteins with multifunctional regulatory domains often demonstrate structural plasticity or protein disorder, allowing the binding of multiple regulatory factors and post-translational modifications. While the importance of protein disorder is clear, it also poses a challenge…
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Keywords:
terminal domain;
intrinsic disorder;
diacylglycerol acyltransferase;
brassica napus ... See more keywords
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Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2022.2103126
Abstract: Abstract A large number of extracts of medicinal plants or natural products shows beneficial to combat obesity. In the present work, a new flavonoid named (2S,1″R,2″R)-4′-hydroxy-7-methoxy-6-(1,2,3-trihydroxy-3-methyl-butyl)-flavanone (1), along with seven known compounds (2–8) were isolated…
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Keywords:
inhibitory activity;
diacylglycerol acyltransferase;
seeds cullen;
cullen corylifolium ... See more keywords
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Published in 2020 at "GCB Bioenergy"
DOI: 10.1111/gcbb.12771
Abstract: Oleaginous algae have the ability to synthesize a high level of triacylglycerol (TAG) and are considered as the next‐generation feedstock for biofuel production. Manipulating algal lipid biosynthetic pathways has potential to overproduce TAG and represents…
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Keywords:
diacylglycerol acyltransferase;
lipid production;
production;
algae ... See more keywords
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Published in 2018 at "Toxicologic Pathology"
DOI: 10.1177/0192623318765909
Abstract: Diacylglycerol acyltransferase 1 (DGAT1) catalyzes the final step in triglyceride synthesis. Since Dgat1 -/- mice fed a high-fat diet (HFD) are resistant to hepatic steatosis, DGAT1 inhibitors are expected to have antifatty liver effects. To…
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Keywords:
hepatic steatosis;
fatty rats;
diacylglycerol acyltransferase;
zucker fatty ... See more keywords
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Published in 2021 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2021.751959
Abstract: Three different cDNA sequences, designated OepPDAT1-1, OepPDAT1-2, and OepPDAT2, encoding three phospholipid:diacylglycerol acyltransferases (PDAT) have been isolated from olive (Olea europaea cv. Picual). Sequence analysis showed the distinctive features typical of the PDAT family and…
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Keywords:
fruit;
pdat;
diacylglycerol;
diacylglycerol acyltransferase ... See more keywords
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Published in 2023 at "Journal of Fungi"
DOI: 10.3390/jof9020219
Abstract: Triacylglycerol (TG) with high-value long-chain polyunsaturated fatty acids is beneficial to human health; consequently, there is an urgent need to broaden its sources due to the current growing demand. Mortierella alpina, one of the most…
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Keywords:
mortierella alpina;
applications diacylglycerol;
production;
triacylglycerol ... See more keywords
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Published in 2023 at "PeerJ"
DOI: 10.7717/peerj.14941
Abstract: Background Soybean (Glycine max) is a major protein and vegetable oil source. In plants, diacylglycerol acyltransferase (DGAT) can exert strong flux control, which is rate-limiting for triacylglycerol biosynthesis in seed oil formation. Methods Here, we…
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Keywords:
dgat;
expression;
diacylglycerol acyltransferase;
glycine max ... See more keywords