α-Arylidene Diacylglycerol-Lactones (DAG-Lactones) as Selective Ras Guanine-Releasing Protein 3 (RasGRP3) Ligands.
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DOI: 10.1021/acs.jmedchem.8b00661
Abstract: Diacylglycerol-lactones have proven to be a powerful template for the design of potent ligands targeting C1 domains, the recognition motif for the cellular second messenger diacylglycerol. A major objective has been to better understand the… read more here.
Keywords: diacylglycerol lactones; selectivity relative; diacylglycerol; fold selectivity ... See more keywords