Targeted therapies in patients with newly diagnosed glioblastoma—A systematic meta‐analysis of randomized clinical trials
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Cancer"
DOI: 10.1002/ijc.34433
Abstract: Glioblastoma (GB) is the most common malignant primary brain tumor in adults. The standard of care for newly diagnosed GB involves surgical resection followed by radiochemotherapy with temozolomide, with or without tumor‐treating fields. In recent… read more here.
Keywords: patients newly; diagnosed glioblastoma; meta analysis; newly diagnosed ... See more keywords
FET PET reveals considerable spatial differences in tumour burden compared to conventional MRI in newly diagnosed glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-018-4188-8
Abstract: PurposeAreas of contrast enhancement (CE) on MRI are usually the target for resection or radiotherapy target volume definition in glioblastomas. However, the solid tumour mass may extend beyond areas of CE. Amino acid PET can… read more here.
Keywords: pet; volume; newly diagnosed; fet pet ... See more keywords
Is surgical resection useful in elderly newly diagnosed glioblastoma patients? Outcome evaluation and prognostic factors assessment
Sign Up to like & getrecommendations! Published in 2018 at "Acta Neurochirurgica"
DOI: 10.1007/s00701-018-3599-4
Abstract: ASTRACTBackgroundThe incidence of glioblastoma among elderly patients is constantly increasing. The value of radiation therapy and concurrent/adjuvant chemotherapy has been widely assessed. So far, the role of surgery has not been thoroughly investigated. The study… read more here.
Keywords: surgery; surgical resection; newly diagnosed; diagnosed glioblastoma ... See more keywords
JCOG0911 INTEGRA study: a randomized screening phase II trial of interferonβ plus temozolomide in comparison with temozolomide alone for newly diagnosed glioblastoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-018-2831-7
Abstract: PurposeThis study explored the superiority of temozolomide (TMZ) + interferonβ (IFNβ) to standard TMZ as treatment for newly diagnosed glioblastoma (GBM) via randomized phase II screening design.Experimental designEligibility criteria included histologically proven GBM, with 50% of the… read more here.
Keywords: phase; trial; newly diagnosed; study ... See more keywords
The impact of the time to start radiation therapy on overall survival in newly diagnosed glioblastoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03137-8
Abstract: PurposeThe standard treatment for newly diagnosed glioblastoma includes maximal safe surgical resection followed by concurrent radiation therapy and temozolomide (TMZ) and maintenance TMZ. The impact of time to start radiation therapy (TRT) on overall survival… read more here.
Keywords: radiation therapy; impact; diagnosed glioblastoma; trt ... See more keywords
Cytoreductive surgery in the management of newly diagnosed glioblastoma in adults: a systematic review and evidence-based clinical practice guideline update
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-020-03606-5
Abstract: These recommendations apply to adults with newly diagnosed or suspected glioblastoma. What is the effect of extent of surgical resection on patient outcome in the initial management of adult patients with suspected newly diagnosed glioblastoma?… read more here.
Keywords: glioblastoma; newly diagnosed; diagnosed glioblastoma; cytoreductive surgery ... See more keywords
Safety and tolerability of asunercept plus standard radiotherapy/temozolomide in Asian patients with newly-diagnosed glioblastoma: a phase I study
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DOI: 10.1038/s41598-021-02527-1
Abstract: Asunercept (company code APG101 [Apogenix AG]; company code CAN008 [CANbridge Pharmaceuticals]) is a novel glycosylated fusion protein that has shown promising effectiveness in glioblastoma. This Phase I study was initiated to evaluate the tolerability and… read more here.
Keywords: glioblastoma phase; glioblastoma; patients newly; diagnosed glioblastoma ... See more keywords
Safety and efficacy of tumour-treating fields (TTFields) therapy for newly diagnosed glioblastoma in Japanese patients using the Novo-TTF System: a prospective post-approval study
Sign Up to like & getrecommendations! Published in 2023 at "Japanese Journal of Clinical Oncology"
DOI: 10.1093/jjco/hyad001
Abstract: Abstract Background Tumour-treating fields therapy is a locoregional, anti-cancer treatment. Efficacy and safety of tumour-treating fields therapy in adults with newly diagnosed glioblastoma were demonstrated in the pivotal phase 3 EF-14 study (NCT00916409). Here, we… read more here.
Keywords: survival; diagnosed glioblastoma; newly diagnosed; treating fields ... See more keywords
OS05.3.A Temporal muscle thickness as surrogate parameter of sarcopenia in newly diagnosed glioblastoma patients:translational imaging analysis of the CENTRIC EORTC 26071-22072 and CORE trials
Sign Up to like & getrecommendations! Published in 2021 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noab180.020
Abstract: Temporal muscle thickness (TMT) was described as surrogate parameter of skeletal muscle mass. This study aimed to investigate the prognostic relevance of TMT in patients with newly diagnosed glioblastoma. TMT was assessed in cranial magnetic… read more here.
Keywords: tmt; newly diagnosed; muscle; study ... See more keywords
Efficacy and safety results of ABT-414 in combination with radiation and temozolomide in newly diagnosed glioblastoma
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DOI: 10.1093/neuonc/now257
Abstract: Background The purpose of this study was to determine the maximum tolerated dose (MTD), recommended phase II dose (RPTD), safety, and pharmacokinetics of ABT-414 plus radiation and temozolomide in newly diagnosed glioblastoma. ABT-414 is a… read more here.
Keywords: newly diagnosed; safety; abt 414; diagnosed glioblastoma ... See more keywords
A randomized phase II study of everolimus in combination with chemoradiation in newly diagnosed glioblastoma: results of NRG Oncology RTOG 0913
Sign Up to like & getrecommendations! Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/nox209
Abstract: Background This phase II study was designed to determine the efficacy of the mammalian target of rapamycin (mTOR) inhibitor everolimus administered daily with conventional radiation therapy and chemotherapy in patients with newly diagnosed glioblastoma. Methods… read more here.
Keywords: newly diagnosed; study; diagnosed glioblastoma; oncology ... See more keywords