A phase 1b study of once‐weekly carfilzomib combined with lenalidomide and dexamethasone in patients with newly diagnosed multiple myeloma
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DOI: 10.1002/ajh.26041
Abstract: Twice‐weekly carfilzomib with lenalidomide‐dexamethasone (Rd) is an effective regimen for newly diagnosed multiple myeloma (NDMM). Here we evaluated once‐weekly carfilzomib with Rd (once‐weekly KRd) in NDMM patients. The NDMM patients were enrolled regardless of transplant… read more here.
Keywords: newly diagnosed; multiple myeloma; weekly carfilzomib; carfilzomib ... See more keywords
Hypercalcemia caused by humoral effects and bone damage indicate poor outcomes in newly diagnosed multiple myeloma patients
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DOI: 10.1002/cam4.3594
Abstract: Hypercalcemia of malignancy (HCM) is a serious metabolic complication, and the highest rates are in multiple myeloma (MM). The cause of hypercalcemia in newly diagnosed multiple myeloma (NDMM) remains unknown. We sought to evaluate the… read more here.
Keywords: newly diagnosed; myeloma; hypercalcemia caused; multiple myeloma ... See more keywords
Ixazomib combined with lenalidomide and dexamethasone chemotherapy for newly diagnosed multiple myeloma in China—Compared with bortezomib/lenalidomide/dexamethasone
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DOI: 10.1002/cam4.5198
Abstract: To compare the response and safety of Ixazomib/Lenalidomide/Dexamethasone (IRd) and Bortezomib/Lenalidomide/Dexamethasone (VRd) treatment in newly diagnosed multiple myeloma (MM). read more here.
Keywords: diagnosed multiple; newly diagnosed; lenalidomide dexamethasone; bortezomib lenalidomide ... See more keywords
Role of BMI and age in predicting pathologic vertebral fractures in newly diagnosed multiple myeloma patients: A retrospective cohort study
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DOI: 10.1002/hon.2486
Abstract: Vertebral fractures affect approximately 30% of myeloma patients and lead to a poor impact on survival and life quality. In general, age and body mass index (BMI) are reported to have an important role in… read more here.
Keywords: newly diagnosed; age; myeloma patients; multiple myeloma ... See more keywords
Slowing processing speed is associated with cognitive fatigue in newly diagnosed multiple sclerosis patients
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DOI: 10.1017/s1355617722000157
Abstract: Abstract Objective: To further investigate objective measures of cognitive fatigue (CF), defined as the inability to sustain performance over time, in newly diagnosed multiple sclerosis (MS) patients, by conducting a performance analysis on the Paced… read more here.
Keywords: sclerosis patients; diagnosed multiple; newly diagnosed; cognitive fatigue ... See more keywords
The impact of induction regimen on transplant outcome in newly diagnosed multiple myeloma in the era of novel agents
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DOI: 10.1038/bmt.2016.214
Abstract: We compared overall survival (OS) of 1017 patients with newly diagnosed multiple myeloma (MM) who were treated with different novel agent-based induction regimens and who underwent early autologous stem cell transplant (ASCT). Subgroups were defined… read more here.
Keywords: newly diagnosed; multiple myeloma; dexamethasone; induction ... See more keywords
Adoption of triplet therapy and clinical outcomes in routine practice among newly diagnosed multiple myeloma patients not receiving frontline stem cell transplant in the USA
Sign Up to like & getrecommendations! Published in 2019 at "Expert Review of Hematology"
DOI: 10.1080/17474086.2019.1555460
Abstract: ABSTRACT Background: Immunomodulator (IMID) and proteasome inhibitor (PI) triplet frontline therapy (FT) in newly diagnosed multiple myeloma (NDMM) trials improve overall survival (OS); reported outcomes in routine practice are lacking. Authors compared outcomes in NDMM… read more here.
Keywords: newly diagnosed; imid triplet; triplet; multiple myeloma ... See more keywords
Real‐world study on adoption of standard‐of‐care for transplant‐eligible newly diagnosed multiple myeloma patients between 2017 and 2020/2021 across France, Germany, Spain, and Italy
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DOI: 10.1111/ejh.13821
Abstract: This non‐interventional observational study described the current standard‐of‐care for transplant‐eligible newly diagnosed multiple myeloma (TE‐NDMM) patients in France, Germany, Spain, and Italy, and recorded the evolution in regimen adoption in distinct elements of frontline treatment… read more here.
Keywords: care transplant; standard care; diagnosed multiple; newly diagnosed ... See more keywords
Prognostic Significance of Blood Transfusion in Newly Diagnosed Multiple Myeloma Patients without Autologous Hematopoietic Stem Cell Transplantation
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DOI: 10.1155/2017/5462087
Abstract: The aim of this study was to evaluate whether blood transfusions affect overall survival (OS) and progression-free survival (PFS) in newly diagnosed multiple myeloma (MM) patients without hematopoietic stem cell transplantation. A total of 181… read more here.
Keywords: newly diagnosed; multiple myeloma; blood; blood transfusion ... See more keywords
Prognostic Nomogram for the Overall Survival of Patients with Newly Diagnosed Multiple Myeloma
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DOI: 10.1155/2019/5652935
Abstract: To establish a nomogram for predicting the overall survival (OS) of patients with newly diagnosed multiple myeloma (MM), 304 patients with newly diagnosed MM were recruited between June 1, 2010, and June 30, 2015, from… read more here.
Keywords: patients newly; newly diagnosed; survival patients; multiple myeloma ... See more keywords
Abstract 6067: Characterizing the landscape of rare structural variant events in newly diagnosed multiple myeloma
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DOI: 10.1158/1538-7445.am2023-6067
Abstract: Background: Structural variants (SV) are known to play a critical role in the pathogenesis of multiple cancer types. Using whole genome sequencing (WGS), we recently characterized the SV landscape of 752 newly diagnosed multiple myeloma… read more here.
Keywords: gene; svs; diagnosed multiple; newly diagnosed ... See more keywords