Direct Catalytic Symmetrical, Unsymmetrical N,N-Dialkylation and Cyclization of Acylhydrazides Using Alcohols.
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DOI: 10.1021/acs.orglett.0c02369
Abstract: Herein, direct N,N-dialkylation of acylhydrazides using alcohols is reported. This catalytic protocol provides one-pot synthesis of both symmetrical and unsymmetrical N,N-disubstituted acylhydrazides using an assortment of primary and secondary alcohols with remarkable selectivity and excellent… read more here.
Keywords: acylhydrazides using; dialkylation; cyclization acylhydrazides; using alcohols ... See more keywords
Nickel-Catalyzed Reductive Alkene Cross-Dialkylation with Unactivated Alkyl Electrophiles.
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DOI: 10.1021/acs.orglett.3c04207
Abstract: A Ni-catalyzed reductive dialkylation of 8-aminoquinoline-tethered aliphatic alkenes with two unactivated alkyl electrophiles is disclosed here. Key to the development of this transformation is the combination of primary alkyl (pseudo)halides and secondary alkyl iodides that… read more here.
Keywords: unactivated alkyl; alkyl electrophiles; dialkylation; reductive alkene ... See more keywords
A Homolytic Substitution Approach for Directing Group-Free Nickel-Catalyzed Dialkylation of Unactivated Alkenes
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DOI: 10.1055/a-2352-4902
Abstract: The selective construction of two C(sp 3 )–C(sp 3 ) bonds through trimolecular cross-coupling of unactivated alkenes remains one of the most difficult challenges in organic synthesis. Despite previous advances in metal-catalyzed coupling for the… read more here.
Keywords: homolytic substitution; unactivated alkenes; dialkylation; catalyzed dialkylation ... See more keywords