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Catalytic Asymmetric Radical Diamination of Alkenes

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1 Published in 2017 at "Chem"

DOI: 10.1016/j.chempr.2017.10.008

Abstract: Summary Catalytic asymmetric diamination of alkenes is a highly attractive method for creating chiral vicinal diamines, which are ubiquitous in biologically active molecules and versatile ligands as well as organocatalysts. We report the use of… read more here.

Keywords: diamination; asymmetric radical; diamination alkenes; reaction ... See more keywords

Removing the Mask in Catalytic Asymmetric Diamination of Alkenes

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0 Published in 2017 at "Chem"

DOI: 10.1016/j.chempr.2017.11.012

Abstract: In this issue of Chem , Liu and co-workers report an extremely general and mild radical diamination protocol that permits the asymmetric synthesis of vicinal diamines in a highly enantioselective manner under a copper(I)/chiral phosphate… read more here.

Keywords: diamination; removing mask; asymmetric diamination; mask catalytic ... See more keywords

Regioselective Three-Component Synthesis of Vicinal Diamines via 1,2-Diamination of Styrenes.

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0 Published in 2021 at "Organic letters"

DOI: 10.1021/acs.orglett.1c00898

Abstract: The vicinal diamine motif plays a significant role in natural products, drug design, and organic synthesis, and development of synthetic methods for the synthesis of diamines is a long-standing interest. Herein, we report a regioselective… read more here.

Keywords: regioselective three; diamination; component synthesis; three component ... See more keywords

Stereoselective Synthesis of Isoxazolidines via Copper-Catalyzed Alkene Diamination.

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0 Published in 2017 at "ACS catalysis"

DOI: 10.1021/acscatal.7b01362

Abstract: A convenient copper-catalyzed intramolecular/intermolecular alkene diamination reaction to synthesize 3-aminomethyl-functionalized isoxazolidines under mild reaction conditions and with generally high levels of diastereoselectivity was achieved. This reaction demonstrates that previously underutilized unsaturated carbamates are good [Cu]-catalyzed… read more here.

Keywords: diamination; stereoselective synthesis; reaction; alkene diamination ... See more keywords

Regiodivergent Iridium(III)-Catalyzed Diamination of Alkenyl Amides with Secondary Amines: Complementary Access to γ- or δ-Lactams.

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0 Published in 2018 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.7b11455

Abstract: Alkenyl N-pivaloylhydroxamates undergo an Ir(III)-catalyzed diamination of the alkene with simple exogenous secondary amines under extraordinarily mild reaction conditions. The regioselectivity of the diamination is controlled by the solvent and the electronics of the cyclopentadienyl… read more here.

Keywords: diamination; secondary amines; regiodivergent iridium; catalyzed diamination ... See more keywords