Diaryl ether derivative inhibits GPX4 expression levels to induce ferroptosis in thyroid cancer cells.
Sign Up to like & getrecommendations! Published in 2023 at "Drug development research"
DOI: 10.1002/ddr.22059
Abstract: Papillary thyroid carcinoma contributes to about 80% of the total thyroid cancer cases. BRAFV600E is a frequently occurring mutation in PTCs. Although several BRAF inhibitors are available, many thyroid cancer patients acquire resistance to BRAF… read more here.
Keywords: thyroid cancer; ferroptosis; cancer cells; diaryl ether ... See more keywords
Diaryl Ether Formation by a Versatile Thioesterase Domain.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c02813
Abstract: Oxidative coupling and oxidative rearrangement are two of the most common biosynthetic strategies to form diaryl ethers. In contrast, enzymatic diaryl ether generation that proceeds in a nonoxidative manner has not been characterized thus far.… read more here.
Keywords: versatile thioesterase; ether formation; thioesterase domain; diaryl ether ... See more keywords
Synthesis of diaryl ether components of ellagitannins using ortho-quinone with consonant mesomeric effects.
Sign Up to like & getrecommendations! Published in 2020 at "Chemical communications"
DOI: 10.1039/d0cc00889c
Abstract: Methods for synthesizing C-O digallate structures, the basic unit of diaryl ether components of natural ellagitannins, are described. In the designed building block derived from gallic acid, consonantly overlapped mesomeric effects enhanced its electrophilicity. This… read more here.
Keywords: mesomeric effects; ether components; synthesis; diaryl ether ... See more keywords