Palladium/Copper-Catalyzed Oxidative Coupling of Arylboronic Acids with Isocyanides: Selective Routes to Amides and Diaryl Ketones.
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DOI: 10.1021/acs.orglett.7b01548
Abstract: An efficient and alternative oxidative cross-coupling strategy starting from arylboronic acids and isocyanides for the selective synthesis of amides and diaryl ketones with palladium/copper catalysis is developed. Various substituted benzamides and benzophenones could be obtained… read more here.
Keywords: palladium copper; acids isocyanides; amides diaryl; arylboronic acids ... See more keywords
Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a "Polar Gate" in Stereorecognition of Diaryl Ketones.
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DOI: 10.1021/jacs.8b08640
Abstract: Diaryl ketones are important building blocks for synthesizing pharmaceuticals and are generally regarded as "difficult-to-reduce" ketones due to the large steric hindrance of their two bulky aromatic side chains. Alcohol dehydrogenase from Kluyveromyces polyspora (… read more here.
Keywords: inversion; polar gate; diaryl; alcohol dehydrogenase ... See more keywords
[2 + 2] Cycloaddition of phosphaalkenes as a key step for the reductive coupling of diaryl ketones to tetraaryl olefins
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DOI: 10.1039/d2sc03073j
Abstract: Procedures for the reductive coupling of carbonyl compounds to alkenes in the literature rely either on a radical coupling strategy, as in the McMurry coupling, or ionic pathways, sometimes catalysed by transition metals, as in… read more here.
Keywords: diaryl ketones; reductive coupling; cycloaddition phosphaalkenes; phosphaalkenes key ... See more keywords
Rhodium-Catalyzed Aryl Migratory/Decarbonylation of Diaryl Ketones via the Activation of Unstrained C–C Bonds
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DOI: 10.1055/a-1561-8299
Abstract: A Rh-catalyzed aryl migratory/decarbonylation of unstrained ketones has been developed. This viable transformation provides a complementary decarbonylative method using diaryl ketones to afford a variety of alkenylated heterocycles in good yields with moderate to good… read more here.
Keywords: diaryl ketones; catalyzed aryl; aryl migratory; migratory decarbonylation ... See more keywords