Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.05.072
Abstract: Microtubule is one of the important targets for cancer treatment. A novel class of diaryl substituted imidazo[4,5-c]pyridin-2-ones and imidazo[4,5-c]pyridines were designed based on combination principles by merging the structures of β-lactams and purine-type compounds known… read more here.
Keywords: diaryl substituted; antitumor activities; design synthesis; tubulin katanin ... See more keywords
Incorporation of norbornene moiety onto the arene of diaryl substituted amides through C-H functionalization
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Organometallic Chemistry"
DOI: 10.1016/j.jorganchem.2017.10.041
Abstract: Abstract In the presence of norbornene, Pd(OAc)2 smoothly catalyzed the meta-C-H activation process of N-phenylbenzamide (4) and yielded a norbornene fused product, (1R,4S,4aR,8bS)-N-phenyl-1,2,3,4,4a,8b-hexahydro-1,4-methanobiphenylene-5-carboxamide (5a). The employment of Ag(OAc) is crucial to the success of this… read more here.
Keywords: incorporation norbornene; moiety onto; arene diaryl; norbornene moiety ... See more keywords
Intramolecular hydroamination of trisubstituted aminoallenes catalyzed by titanium complexes of diaryl substituted tridentate imine-diols
Sign Up to like & getrecommendations! Published in 2021 at "Polyhedron"
DOI: 10.1016/j.poly.2021.115070
Abstract: Abstract Our laboratory has developed catalysts based on earth abundant titanium for asymmetric reactions including intramolecular hydroamination. Previously, we showed that titanium complexes of imine diol ligands showed improved enantioselectivity relative to complexes with bidentate… read more here.
Keywords: diaryl substituted; titanium complexes; intramolecular hydroamination; hydroamination ... See more keywords
Construction of highly enantiopure β,β-diaryl substituted glycine containing two contiguous stereocenters via asymmetric 1,6-conjugate addition
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.05.057
Abstract: Abstract Asymmetric construction of β,β-diaryl substituted glycine bearing two contiguous chiral centers remains a significant challenge. Herein, the application of the para-quinone methides (p-QMs) and Ni(II)- complex of glycine via 1,6-conjugate addition to achieve asymmetric… read more here.
Keywords: two contiguous; highly enantiopure; conjugate addition; substituted glycine ... See more keywords
Vicinal Diaryl-Substituted Isoxazole and Pyrazole Derivatives with In Vitro Growth Inhibitory and In Vivo Antitumor Activity
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c03405
Abstract: The vicinal diaryl heterocyclic framework has been widely used for the development of compounds with significant bioactivities. In this study, a series of diaryl heterocycles were designed and synthesized based on an in-house diaryl isoxazole… read more here.
Keywords: antitumor; antitumor activity; vicinal diaryl; diaryl substituted ... See more keywords
6,6′-Diaryl-substituted biazulene diimides for solution-processable high-performance n-type organic semiconductors
Sign Up to like & getrecommendations! Published in 2018 at "Materials Chemistry Frontiers"
DOI: 10.1039/c8qm00047f
Abstract: Azulene, a non-benzenoid aromatic hydrocarbon, is a promising building block for constructing organic optoelectronic materials. Herein, a series of 6,6′-diaryl-substituted biazulene diimides (1–5) are designed and synthesized for solution-processable organic semiconductors. These compounds exhibited excellent… read more here.
Keywords: solution processable; substituted biazulene; organic semiconductors; diaryl substituted ... See more keywords