Discovery of novel anti-angiogenesis agents. Part 8: Diaryl thiourea bearing 1H-indazole-3-amine as multi-target RTKs inhibitors.
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DOI: 10.1016/j.ejmech.2017.10.008
Abstract: VEGFR-2, TIE-2, and EphB4 are essential for both angiogenesis and tumorigenesis. Herein, we designed and prepared three classes of multi-target inhibitors based on the extensive sequence homology along the kinase domain of angiogenic RTKs. Biological… read more here.
Keywords: target; diaryl thiourea; novel anti; indazole amine ... See more keywords