Discovery of 2,4-diarylaminopyrimidine derivatives bearing dithiocarbamate moiety as novel FAK inhibitors with antitumor and anti-angiogenesis activities.
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DOI: 10.1016/j.ejmech.2019.05.048
Abstract: A series of 2,4-diarylaminopyrimidine derivatives containing dithiocarbamate moiety were designed by molecular hybridization strategy and synthesized for screening as inhibitors of focal adhesion kinase (FAK). Most of these compounds exhibit significant antiproliferative activities on human… read more here.
Keywords: diarylaminopyrimidine derivatives; dithiocarbamate moiety; anti angiogenesis;