Antiplasmodial and Antimalarial Activity of 3,5‐Diarylidenetetrahydro‐2H‐pyran‐4(3H)‐ones via Inhibition of Plasmodium falciparum Pyridoxal Synthase
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DOI: 10.1002/cmdc.202200411
Abstract: A series of 22 different 3,5‐diarylidenetetrahydro‐2H‐pyran‐4(3H)‐ones (DATPs) were synthesized, characterized, and screened for their in vitro antiplasmodial activities against chloroquine (CQ)‐sensitive Pf3D7, CQ‐resistant PfINDO, and artemisinin‐resistant PfMRA‐1240 strains of Plasmodium falciparum. DATP 19 (3,5‐bis(4‐hydroxy‐3,5‐dimethoxybenzylidene)tetrahydro‐2H‐pyran‐4(3H)‐one) was found… read more here.
Keywords: plasmodium falciparum; pyran ones; tetrahydro pyran; diarylidenetetrahydro pyran ... See more keywords