Palladium-catalyzed diastereoselective synthesis of β,β-diarylpropionic acid derivatives and its application to the total synthesis of (R)-tolterodine and the enantiomer of a key intermediate for MK-8718
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DOI: 10.1016/j.tetlet.2017.12.082
Abstract: Abstract Palladium-catalyzed diastereoselective synthesis of optically active β,β-diarylpropionic acid derivatives employing 4-(tert-butyl)oxazolidin-2-one as the chiral auxiliary under an air atmosphere in excellent yields with high diastereoselectivity is reported. The catalytic system is applied to the… read more here.
Keywords: diastereoselective synthesis; synthesis; catalyzed diastereoselective; palladium catalyzed ... See more keywords