A Diastereoselective Cascade Annulation Approach to Bridged Polycyclic Heterocycles Involving an Unexpected Rearrangement.
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DOI: 10.1021/acs.orglett.2c03629
Abstract: A diastereoselective cascade annulation between allenoates and in-situ generated isoquinoline N-oxides generating sp3-rich bridged polycyclic heterocycles is disclosed. The reaction proceeds through an unprecedented non-rearomatized rearrangement and allows access to a broad range of bridged… read more here.
Keywords: bridged polycyclic; cascade annulation; diastereoselective cascade; polycyclic heterocycles ... See more keywords