Ag(I)/PPh3-catalyzed diastereoselective syntheses of spiro[indole-3,4'-piperidine] derivatives via cycloisomerizations of tryptamine-ynamides.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc07298f
Abstract: A Ag(I)/PPh3-catalyzed chelation-controlled cycloisomerization of tryptamine-ynamide was developed to access the spiro[indole-3,4'-piperidine] scaffold in a racemic and diastereoselective manner. The diastereoselective products were achieved by a chiron approach. Density functional theory (DFT) calculations indicated that… read more here.
Keywords: diastereoselective syntheses; catalyzed diastereoselective; indole piperidine; pph3 catalyzed ... See more keywords