Diastereoselective synthesis of a cyclic diamide-bridged biphenyl as chiral atropos ligand.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23434
Abstract: Chiral compounds with a 1,2-diamine structure motif and their derivatives are of great interest in organic chemistry and are broadly used in asymmetric transformations, as chiral auxiliaries, (co)ligands, and ligand core structure. Here, we present… read more here.
Keywords: diastereoselective synthesis; atropos; ligand; diamide bridged ... See more keywords
First Tandem‐Type One‐Pot Process Combining Asymmetric Organo‐ and Biocatalytic Reactions in Aqueous Media Exemplified for the Enantioselective and Diastereoselective Synthesis of 1,3‐Diols
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201600831
Abstract: A suitable "process window" was identified for the combination of an asymmetric organocatalytic aldol reaction and subsequent biocatalytic reduction in aqueous medium, which thus enabled the enantio- and diastereoselective synthesis of 1,3-diols in a tandem-type,… read more here.
Keywords: diastereoselective synthesis; synthesis diols; process; one pot ... See more keywords
ONE-POT DIASTEREOSELECTIVE SYNTHESIS OF FUNCTIONALIZED 4,5-DIHYDROPYRROLES BY REACTIONS OF ARYLGLYOXALS, β-DICARBONYL COMPOUNDS, AND AROMATIC AMINES
Sign Up to like & getrecommendations! Published in 2019 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/5055
Abstract: A multicomponent reaction of arylglyoxal hydrates, acetylacetone or acetoacetic ester, aniline or its 3(4)-substituted analogs in 1:1:2 ratio occurred upon stirring in methanol, giving 4-arylamino-5-hydroxypyrroline derivatives containing 4,5-dihydroxypyrrolines as impurities. read more here.
Keywords: diastereoselective synthesis; synthesis functionalized; functionalized dihydropyrroles; dihydropyrroles reactions ... See more keywords
REGIO- AND DIASTEREOSELECTIVE SYNTHESIS OF N -SUBSTITUTED 2-ACYL-3-ARYL-3,5-DIHYDROFURO[3,2- c ]PYRIDIN-4(2 H )-ONES
Sign Up to like & getrecommendations! Published in 2020 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/5898
Abstract: Трехкомпонентной конденсацией генерируемых in situ ацилметилидов пиридиния с ароматическими альдегидами и 4-гидрокси-6-метилпиридонами получена серия 3-арил-2-ацил-3,5-дигидрофуро[3,2- c ]пиридин-4(2 H )-онов. Реакция протекает диастереоселективно с образованием транс -изомеров и представляет собой каскадный процесс, включающий конденсацию Кнёвенагеля, карбо-реакцию… read more here.
Keywords: diastereoselective synthesis; synthesis substituted; regio diastereoselective; acyl aryl ... See more keywords
Highly regio- and diastereoselective synthesis of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles, based on a post-Ugi condensation: joint experimental and computational study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01632-3
Abstract: A novel series of oxo-1,2,3,4-tetrahydropyrazino[1,2-a]indoles were synthesized via a two-step pathway. In the first step, Ugi-four-component condensation of 2-formylindole, amines, (E)-4-alkoxy-4-oxobut-2-enoic acids, and isocyanides gave the corresponding Ugi-adducts. This adduct underwent intramolecular hydroamination in the… read more here.
Keywords: oxo tetrahydropyrazino; condensation; diastereoselective synthesis; tetrahydropyrazino indoles ... See more keywords
The first target specific, highly diastereoselective synthesis, design and characterization of pyranoquinolinyl acrylic acid diastereomers as potential α-glucosidase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2018.11.026
Abstract: In the present investigation we report the first target specific, highly diastereoselective synthesis of new class of pyranoquinolinyl/furoquinolinyl-acrylic acid diastereomers and evaluation of their invitro α-glucosidase inhibitory activity. All the products were thoroughly characterized by… read more here.
Keywords: target specific; diastereoselective synthesis; acrylic acid; highly diastereoselective ... See more keywords
Diastereoselective synthesis of polyfluoroalkylated α-aminophosphonic acid derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2018.10.001
Abstract: Abstract The asymmetric synthesis of biorelevant aminophosphonates and aminophosphonic acids bearing trifluoromethyl, tetrafluoroethyl, perfluoropropyl or chlorodifluoromethyl group in the α-position to phosphonyl group is developed. Diastereoselective reduction of α-(poly)fluoroalkylated iminophosphonates, bearing stereodirecting α-phenylethyl group at… read more here.
Keywords: aminophosphonic acid; diastereoselective synthesis; group; synthesis polyfluoroalkylated ... See more keywords
Diastereoselective synthesis and anticancer potential of a small library of cage-like heterocyclic hybrids
Sign Up to like & getrecommendations! Published in 2021 at "Journal of King Saud University - Science"
DOI: 10.1016/j.jksus.2020.101238
Abstract: Abstract With an aim to construct novel anticancer drugs, a series of polycyclic heterocycles comprising diverse structural sub-units based on molecular hybridization strategy have been designed and synthesized through a three-component [3+2]-cycloaddition/annulation strategy. Anticancer evaluation… read more here.
Keywords: diastereoselective synthesis; synthesis anticancer; potential small; anticancer ... See more keywords
Diastereoselective synthesis of trans-2,3-dihydrofuro[3,2-c]coumarins by MgO nanoparticles under ultrasonic irradiation
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Saudi Chemical Society"
DOI: 10.1016/j.jscs.2016.01.003
Abstract: MgO nanoparticles have been used as an efficient catalyst for the diastereoselective preparation of trans-2-benzoyl-3-(aryl)-2H-furo[3,2-c]chromen-4(3H)-ones by the multi-component reaction of 2,4′-dibromoacetophenone, pyridine, benzaldehydes and 4-hydroxycoumarin under ultrasonic irradiation. This interesting result revealed that the pyridiniumylide… read more here.
Keywords: diastereoselective synthesis; synthesis trans; ultrasonic irradiation; mgo nanoparticles ... See more keywords
A diastereoselective synthesis of functionalized bis-spirorhodanine-linked cyclopentanes via C(sp3)–H activation
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron"
DOI: 10.1016/j.tet.2018.06.029
Abstract: Abstract A diastereoselective synthesis of bis-spirorhodanine-linked cyclopentane derivatives via the [2 + 2+1] cycloaddition reaction between alkyl (Z)-2-(3-alkyl-4-oxo-2-thioxothiazolidin-5-ylidene)acetates (alkylidenerhodanines) and azomethine ylides, prepared in situ from iodine mediated reaction of 2-methylquinoline and pyridine in the presence of… read more here.
Keywords: diastereoselective synthesis; synthesis functionalized; spirorhodanine linked; bis spirorhodanine ... See more keywords
Palladium-catalyzed diastereoselective synthesis of β,β-diarylpropionic acid derivatives and its application to the total synthesis of (R)-tolterodine and the enantiomer of a key intermediate for MK-8718
Sign Up to like & getrecommendations! Published in 2018 at "Tetrahedron Letters"
DOI: 10.1016/j.tetlet.2017.12.082
Abstract: Abstract Palladium-catalyzed diastereoselective synthesis of optically active β,β-diarylpropionic acid derivatives employing 4-(tert-butyl)oxazolidin-2-one as the chiral auxiliary under an air atmosphere in excellent yields with high diastereoselectivity is reported. The catalytic system is applied to the… read more here.
Keywords: diastereoselective synthesis; synthesis; catalyzed diastereoselective; palladium catalyzed ... See more keywords