Rational design of Kluyveromyces marxianus ZJB14056 aldo-keto reductase KmAKR to enhance diastereoselectivity and activity.
Sign Up to like & getrecommendations! Published in 2017 at "Enzyme and microbial technology"
DOI: 10.1016/j.enzmictec.2017.07.012
Abstract: t-Butyl 6-cyano-(3R,5R)-dihydroxyhexanoate ((3R,5R)-1b) is a valuable chiral synthon of atorvastatin calcium. A novel NADPH-specific aldo-keto reductase (AKR) was identified from a thermotolerant yeast Kluyveromyces marxianus ZJB14056 by genome database mining, displaying t-butyl 6-cyano-(5R)-hydroxy-3-oxohexanoate ((5R)-1a) reducing… read more here.
Keywords: aldo keto; diastereoselectivity; marxianus zjb14056; kluyveromyces marxianus ... See more keywords
Diastereoselectivity of cyclopropanation of substituted α-fluorostyrenes versus styrenes by different methods
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Fluorine Chemistry"
DOI: 10.1016/j.jfluchem.2017.09.008
Abstract: Abstract The diastereoselectivity of cyclopropanations of styrene and α-fluorostyrene with diazoacetate depends on the catalyst used and the presence or absence of the fluorine substituent. The Cu(acac) 2 catalyzed reaction of styrene with diazoacetate led… read more here.
Keywords: substituted fluorostyrenes; diastereoselectivity; diastereoselectivity cyclopropanation; diazoacetate ... See more keywords
Controlling the Gold(I)-Catalyzed 1,5-Allenene Reaction: Construction of Fused Rings with Excellent Diastereoselectivity.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c03886
Abstract: In the present study, the gold(I)-catalyzed reaction of 1,5-allenenes was controlled in such a way that instead of a [2 + 3] cycloaddition, a 5-exo-cyclization with the formation of a carbocation occurred. The latter could… read more here.
Keywords: diastereoselectivity; controlling gold; catalyzed allenene; reaction ... See more keywords
Substrate access path-guided engineering of L-threonine aldolase for improving diastereoselectivity.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc02644a
Abstract: The L-threonine aldolase from Leishmania major was engineered to improve its diastereoselectivity by a CAST/ISM strategy, providing insights into the relationship between the physico-chemical properties of the substrate access path and diastereoselectivity. The steric hindrance,… read more here.
Keywords: access path; substrate access; diastereoselectivity; threonine aldolase ... See more keywords