A Two-Step Kinugasa/Conia-Ene-Type Sequential Reaction for Asymmetric Synthesis of 8-Methylene -2,6-diazaspiro [3.4]octane-1,5-diones
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DOI: 10.1039/d4qo01388c
Abstract: 2,6-Diazaspiro[3.4]octane-1,3-dione, integrating -lactam and -lactam into one structure, is an important skeleton found in many bioactive molecules. This article describes a simple and practical synthesis of 8-methylene-2,6-diazaspiro[3.4]octane-1,5-diones from N-(prop-2-yn-1-yl)propiolamides... read more here.
Keywords: diazaspiro; synthesis methylene; methylene diazaspiro; octane diones ... See more keywords