Evaluation of Pharmacokinetics and Dose Proportionality of Diazepam After Intranasal Administration of NRL‐1 to Healthy Volunteers
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.767
Abstract: NRL‐1 is a novel intranasal formulation of diazepam that is being evaluated as rescue medication in patients with epilepsy who experience bouts of increased seizure activity despite stable regimens of antiepileptic drugs. This phase 1,… read more here.
Keywords: administration; time; dose proportionality; concentration ... See more keywords
High-throughput and trace analysis of diazepam in plasma using DART-MS/MS and its pharmacokinetic application.
Sign Up to like & getrecommendations! Published in 2021 at "Analytical biochemistry"
DOI: 10.1016/j.ab.2021.114435
Abstract: A high-throughput quantitative analytical method based on Direct Analysis in Real Time tandem mass spectrometry (DART-MS/MS) has been developed and validated for the determination of diazepam in rat plasma, whereby analyzing of each sample needs… read more here.
Keywords: plasma; analysis; application; diazepam ... See more keywords
Making Sense of a Negative Clinical Trial Result: A Bayesian Analysis of a Clinical Trial of Lorazepam and Diazepam for Pediatric Status Epilepticus
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Emergency Medicine"
DOI: 10.1016/j.annemergmed.2016.08.449
Abstract: Study objective: We demonstrate the application of a Bayesian approach to a recent negative clinical trial result. A Bayesian analysis of such a trial can provide a more useful interpretation of results and can incorporate… read more here.
Keywords: clinical trial; trial; analysis; study ... See more keywords
Diazepam suppresses the stress‐induced dopaminergic release in the amygdala of methamphetamine‐sensitized rat
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.05.048
Abstract: Abstract Although the benzodiazepine class of drugs has proven useful in treating anxiety symptoms, recent studies yield no consistent empirical support for their use in treating psychiatric disorders. However, animal studies using a fear conditioning… read more here.
Keywords: memory processing; amygdala methamphetamine; fear memory; effect ... See more keywords
Reaction of diazepam and related benzodiazepines with chlorine. Kinetics, transformation products and in-silico toxicological assessment.
Sign Up to like & getrecommendations! Published in 2017 at "Water research"
DOI: 10.1016/j.watres.2017.04.063
Abstract: In this work, the reaction of four benzodiazepines (diazepam, oxazepam, nordazepam and temazepam) during water chlorination was studied by means of liquid chromatography-quadrupole-time of flight-mass spectrometry (LC-QTOF-MS). For those compounds that showed a significant degradation,… read more here.
Keywords: oxazepam nordazepam; water; transformation; reaction ... See more keywords
Ocular disposition of diazepam in rabbits: understanding its level in vitreous humour for forensic applications
Sign Up to like & getrecommendations! Published in 2017 at "Australian Journal of Forensic Sciences"
DOI: 10.1080/00450618.2016.1205661
Abstract: The disadvantages associated with routine toxicological samples, such as blood samples, have encouraged the forensic toxicologist to use vitreous humour as an alternative matrix. However, its use is still limited. The reason for this is… read more here.
Keywords: disposition; vitreous humour; study; blood ... See more keywords
Antibacterial activity of diazepam against planktonic and biofilm strains of methicillin-resistant Staphylococcus aureus
Sign Up to like & getrecommendations! Published in 2025 at "Biofouling"
DOI: 10.1080/08927014.2025.2540534
Abstract: Abstract The aim was to evaluate the antibacterial activity of diazepam against methicillin-susceptible (MSSA) and methicillin-resistant (MRSA) strains of Staphylococcus aureus and its possible mechanism of action. The broth microdilution assay was used to determine… read more here.
Keywords: antibacterial activity; activity diazepam; staphylococcus aureus; methicillin resistant ... See more keywords
Should chlordiazepoxide and diazepam be avoided when treating alcohol withdrawal syndrome in patients with hepatic insufficiency?
Sign Up to like & getrecommendations! Published in 2025 at "Clinical Toxicology"
DOI: 10.1080/15563650.2025.2493216
Abstract: Abstract Introduction Chlordiazepoxide and diazepam are first-line treatments for patients with alcohol withdrawal. However, their use is discouraged in hepatic insufficiency due to concerns that impaired metabolism may prolong their half-lives and those of their… read more here.
Keywords: insufficiency; chlordiazepoxide; patients hepatic; alcohol withdrawal ... See more keywords
Dual effects of anandamide in the antiepileptic activity of diazepam in pentylenetetrazole-induced seizures in mice
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Pharmacology"
DOI: 10.1097/fbp.0000000000000700
Abstract: The prototype endocannabinoid, anandamide activates both CB1 and transient receptor potential vanilloid type 1 channels (TRPV1) receptor at different concentrations. At high concentrations, anandamide-mediated TRPV1 effects are opposite to its effects at low concentrations via… read more here.
Keywords: dual effects; diazepam; 100 mouse; effects anandamide ... See more keywords
A case of lethal suicidal intoxication with propafenone and diazepam
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Noninvasive Electrocardiology"
DOI: 10.1111/anec.13111
Abstract: Diazepam poisoning is a common emergency situation, but propafenone poisoning is relatively rare. We reported a case of propafenone poisoning combined with diazepam. An 18‐year‐old female patient was admitted to our hospital with an overdose… read more here.
Keywords: propafenone; propafenone diazepam; lethal suicidal; case lethal ... See more keywords
Lack of clinically relevant differences in safety and pharmacokinetics after second‐dose administration of intranasal diazepam within 4 h for acute treatment of seizure clusters: A population analysis
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsia"
DOI: 10.1111/epi.17249
Abstract: Current diazepam nasal spray labeling requires waiting 4 h before administering a second dose. The objective of the current analyses was to examine safety and pharmacokinetic profiles of second doses of diazepam nasal spray given… read more here.
Keywords: safety; lack clinically; second dose; relevant differences ... See more keywords