Consistent safety and tolerability of Valtoco® (diazepam nasal spray) in relationship to usage frequency in patients with seizure clusters: Interim results from a phase 3, long‐term, open‐label, repeat‐dose safety study
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DOI: 10.1002/epi4.12494
Abstract: Need for rescue therapy differs among patients with seizure clusters. Diazepam nasal spray is approved to treat seizure clusters in patients with epilepsy ≥6 years of age. This analysis used interim data from a phase… read more here.
Keywords: patients seizure; diazepam nasal; safety; seizure clusters ... See more keywords
Exploring proposed recommendations for immediate‐use seizure medication: Treating both cluster and prolonged seizures with diazepam nasal spray
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DOI: 10.1002/epi4.70054
Abstract: The Seizure Termination Project developed expert consensus recommendations for outpatient management of seizure clusters and prolonged seizures to prevent progression to a higher‐level emergency. The consensus recommendations described therapeutic scenarios for seizure clusters (acute cluster… read more here.
Keywords: diazepam nasal; prolonged seizures; seizure clusters; seizure ... See more keywords
Evaluation of diazepam nasal spray in patients with epilepsy concomitantly using maintenance benzodiazepines: An interim subgroup analysis from a phase 3, long‐term, open‐label safety study
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DOI: 10.1111/epi.16901
Abstract: Diazepam nasal spray (Valtoco), indicated for acute treatment of frequent seizure activity (seizure clusters) in patients with epilepsy ≥6 years of age, is designed to be a rapid, noninvasive, socially acceptable route of administration. This… read more here.
Keywords: diazepam nasal; patients epilepsy; nasal spray;
A randomized, open‐label, two‐treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults
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DOI: 10.1111/epi.17459
Abstract: The pharmacokinetics of oral diazepam are affected by food, but food‐effect studies have not been conducted for diazepam nasal spray because it is believed that most absorption occurs via the nasal mucosa. However, gastrointestinal side… read more here.
Keywords: diazepam nasal; food; study evaluate; nasal spray ... See more keywords
Diazepam nasal spray administration is effective to control seizure clusters irrespective of time of day
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DOI: 10.3389/fneur.2024.1335421
Abstract: Introduction Neurologic circadian influences, including sleep/wake transitions, processes (e.g., hormonal variation), and behavioral patterns (e.g., consumption of food and oral medications), may affect seizure patterns. Specific circadian patterns of seizures have been reported depending on… read more here.
Keywords: diazepam nasal; seizure; time day; nasal spray ... See more keywords