Exploiting the Continuous In Situ Generation of Mesyl Azide for Use in a Telescoped Process
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.201700871
Abstract: The hazardous diazo transfer reagent mesyl azide, has been safely generated and used in situ for continuous diazo transfer as part of an integrated synthetic process with an embedded safety quench. Diazo transfer to β-ketoesters… read more here.
Keywords: mesyl azide; situ generation; exploiting continuous; process ... See more keywords
Unexpected Ring Contraction of Homophthalic Anhydrides under Diazo Transfer Conditions.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01730
Abstract: An attempted Regitz diazo transfer onto homophthalic anhydride led to the discovery of an unexpected ring contraction, which gave N-sulfonyl phthalide-3-carboxamide derivatives. The reaction is thought to proceed via a [3 + 2] cycloaddition of… read more here.
Keywords: ring contraction; diazo transfer; unexpected ring; contraction homophthalic ... See more keywords
The Reactivity of Azidonitrobenzofuroxans towards 1,3-Dicarbonyl Compounds: Unexpected Formation of Amino Derivative via the Regitz Diazo Transfer and Tautomerism Study
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22179646
Abstract: Herein, we report on the reaction of nitro-substituted azidobenzofuroxans with 1,3-dicarbonyl compounds in basic media. The known reactions of benzofuroxans and azidofuroxans with 1,3-dicarbonyl compounds in the presence of bases are the 1,3-dipolar cycloaddition and… read more here.
Keywords: reactivity azidonitrobenzofuroxans; regitz diazo; dicarbonyl compounds; diazo transfer ... See more keywords
Improved Diazo-Transfer Reaction for DNA-Encoded Chemistry and Its Potential Application for Macrocyclic DEL-Libraries
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26061790
Abstract: DNA-encoded libraries (DEL) are increasingly being used to identify new starting points for medicinal chemistry in drug discovery. Herein, we discuss the development of methods that allow the conversion of both primary amines and anilines,… read more here.
Keywords: improved diazo; dna; chemistry; dna encoded ... See more keywords