Rh(III)-Catalyzed Defluorinative [4 + 2] Annulation of N-Sulfonylarylamides with Ethyl 2-Diazo-3,3,3-trifluoropropanoate: Synthesis of 1,3,4-Functionalized Isoquinolines.
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DOI: 10.1021/acs.orglett.2c03501
Abstract: Using 2-diazo-3,3,3-trifluoropropanoate as a nontraditional two-carbon reaction partner, a Rh(III)-catalyzed defluorinative [4 + 2] annulation for the synthesis of 1,3,4-functionalized isoquinolines was developed. The reaction proceeds by sequential C-H carbenoid insertion, dual C-F bond cleavage/annulation,… read more here.
Keywords: catalyzed defluorinative; synthesis functionalized; annulation; defluorinative annulation ... See more keywords