iTrEnDi: In Situ Trimethylation Enhancement Using Diazomethane: Improved and Expanded Glycerophospholipid and Sphingolipid Analyses via a Microscale Autonomous Derivatization Platform.
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DOI: 10.1021/acs.analchem.0c04088
Abstract: Trimethylation enhancement using diazomethane (TrEnDi) is a derivatization technique that significantly enhances the signal intensity of glycerophospholipid species in mass spectrometry (MS) and tandem mass spectrometry (MS/MS) analyses. Here, we describe a novel apparatus that… read more here.
Keywords: itrendi; using diazomethane; diazomethane; trimethylation enhancement ... See more keywords
Lab-scale production of anhydrous diazomethane using membrane separation technology
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DOI: 10.1038/nprot.2017.046
Abstract: Diazomethane is among the most versatile and useful reagents for introducing methyl or methylene groups in organic synthesis. However, because of its explosive nature, its generation and purification by distillation are accompanied by a certain… read more here.
Keywords: using membrane; diazomethane; membrane separation; diazomethane using ... See more keywords
A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU
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DOI: 10.1039/c6gc03066a
Abstract: Diazomethane is a valuable C1-building block for organic synthesis. Due to its intrinsic reactivity and instability, handling of this reagent is associated with serious safety hazards. Herein we present a simple and robust continuous flow… read more here.
Keywords: diazomethane; scalable safe; continuous flow; generation diazomethane ... See more keywords
Atmospheric chemistry of diazomethane – an experimental and theoretical study
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DOI: 10.1080/00268976.2020.1718227
Abstract: The kinetics of the O3, OH and NO3 radical reactions with diazomethane were studied in smog chamber experiments employing long-path FTIR and PTR-ToF-MS detection. The rate coefficients were determined to be k CH2NN+O3 = (3.2 ± 0.4) × 10−17 and k… read more here.
Keywords: diazomethane; chemistry; diazomethane experimental; atmospheric chemistry ... See more keywords