Human pregnane X receptor is activated by dibenzazepine carbamate-based inhibitors of constitutive androstane receptor
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Toxicology"
DOI: 10.1007/s00204-017-1948-3
Abstract: Unintentional activation of xenosensing nuclear receptors pregnane X receptor (PXR) and/or constitutive androstane receptor (CAR) by clinical drug use is known to produce severe side effects in patients, which may be overcome by co-administering antagonists.… read more here.
Keywords: pregnane receptor; dibenzazepine carbamate; pxr; receptor ... See more keywords