Discovery of Aporphine Analogues as Potential Antiplatelet and Antioxidant Agents: Design, Synthesis, Structure–Activity Relationships, Biological Evaluations, and in silico Molecular Docking Studies
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DOI: 10.1002/cmdc.201800318
Abstract: To explore the potential of aporphine alkaloids, a novel series of functionalized aporphine analogues with alkoxy (OCH3, OC2H5, OC3H7) functional groups at C1/C2 of ring A and an acyl (COCH3 and COPh) or phenylsulfonyl (SO2Ph and… read more here.
Keywords: dibenzo; dibenzo quinoline; trimethoxy; aporphine analogues ... See more keywords
Cascade intramolecular imidoylation and C-H activation/annulation of benzimidoyl chlorides with alkynes: one-pot synthesis of 7H-dibenzo[de,h]quinoline analogues.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc03400e
Abstract: Reported herein is a cascade Lewis acid-promoted intramolecular Friedel-Crafts-type imidoylation and Rh(iii)-catalyzed C-H activation/annulation of benzimidoyl chlorides and alkynes, providing a general and concise one-pot approach to 7H-dibenzo[de,h]quinoline analogues. This divergent approach is based on… read more here.
Keywords: annulation benzimidoyl; dibenzo quinoline; chlorides alkynes; activation annulation ... See more keywords