Conjugation of Short Peptides to Dibenzodiazepinone-Type Muscarinic Acetylcholine Receptor Ligands Determines M2R Selectivity.
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DOI: 10.1021/acs.jmedchem.8b01967
Abstract: Muscarinic acetylcholine receptors (MRs), comprising five subtypes (M1R-M5R) in humans, exhibit a high degree of structural similarity. Therefore, subtype-selective MR agonists and antagonists are lacking. We present an approach to highly M2R-selective MR antagonists based… read more here.
Keywords: conjugation; m2r selectivity; muscarinic acetylcholine; dibenzodiazepinone type ... See more keywords