Diboronic Acid Anhydride-Catalyzed Direct Peptide Bond Formation Enabled by Hydroxy-Directed Dehydrative Condensation.
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DOI: 10.1021/acs.orglett.0c03252
Abstract: We report the catalytic direct peptide bond formations via dehydrative condensation of β-hydroxy-α-amino acids, affording the serine, threonine, or β-hydroxyvaline-derived peptides in high to excellent yields with high functional group tolerance, minimum epimerization, and excellent… read more here.
Keywords: hydroxy directed; diboronic acid; acid anhydride; dehydrative condensation ... See more keywords