miR‐122 promotes metastasis of clear‐cell renal cell carcinoma by downregulating Dicer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31050
Abstract: Although overall downregulation of microRNAs (miRNAs) is a general feature of clear‐cell renal cell carcinoma (ccRCC), several miRNAs are consistently upregulated, among which miR‐122 was markedly increased in ccRCC tissues. Our study aims to determine… read more here.
Keywords: cell renal; ccrcc; dicer; mir 122 ... See more keywords
Caspase-mediated cleavage of miRNA processing proteins Drosha, DGCR8, Dicer, and TRBP2 in heat-shocked cells and its inhibition by HSP70 overexpression
Sign Up to like & getrecommendations! Published in 2021 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-021-01242-0
Abstract: Cells respond to stress through adaptive mechanisms that limit cellular damage and prevent cell death. MicroRNAs act as regulators of stress responses and stress can impact the functioning of miRNA biogenesis pathways. We were interested… read more here.
Keywords: mirna processing; trbp2; cleavage; overexpression ... See more keywords
Role of Dicer in regulating oxaliplatin resistance of colon cancer cells.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.10.071
Abstract: Colorectal cancer (CRC) is a major health problem due to its high mortality rate. The incidence of CRC is increasing in young individuals. Oxaliplatin (OXA) is an approved third-generation drug and is used for first-line… read more here.
Keywords: dicer; role dicer; resistance; crc ... See more keywords
Dicer Deficiency Differentially Impacts Microglia of the Developing and Adult Brain
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.05.003
Abstract: Summary Microglia seed the embryonic neuro‐epithelium, expand and actively sculpt neuronal circuits in the developing central nervous system, but eventually adopt relative quiescence and ramified morphology in the adult. Here, we probed the impact of… read more here.
Keywords: adult; dicer; developing adult; microglia developing ... See more keywords
Ago2-Dependent Processing Allows miR-451 to Evade the Global MicroRNA Turnover Elicited during Erythropoiesis.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular cell"
DOI: 10.1016/j.molcel.2020.02.020
Abstract: MicroRNAs (miRNAs) are sequentially processed by two RNase III enzymes, Drosha and Dicer. miR-451 is the only known miRNA whose processing bypasses Dicer and instead relies on the slicer activity of Argonaute-2 (Ago2). miR-451 is… read more here.
Keywords: processing; ago2 dependent; dependent processing; dicer ... See more keywords
Identifying and removing widespread signal deflections from fMRI data: Rethinking the global signal regression problem
Sign Up to like & getrecommendations! Published in 2020 at "NeuroImage"
DOI: 10.1016/j.neuroimage.2020.116614
Abstract: One of the most controversial procedures in the analysis of resting-state functional magnetic resonance imaging (rsfMRI) data is global signal regression (GSR): the removal, via linear regression, of the mean signal averaged over the entire… read more here.
Keywords: global signal; gsr; regression; dicer ... See more keywords
RNA interference of Dicer-1 and Argonaute-1 increasing the sensitivity of Aphis gossypii Glover (Hemiptera: Aphididae) to plant allelochemical.
Sign Up to like & getrecommendations! Published in 2017 at "Pesticide biochemistry and physiology"
DOI: 10.1016/j.pestbp.2017.03.003
Abstract: Plant allelochemicals are a group of important defensive agents of plants, which have been documented to be deleterious to insect herbivores. In the present study, we found that the expression level of Dicer-1 was significantly… read more here.
Keywords: plant allelochemicals; plant; aphis gossypii; rna ... See more keywords
Comparative Biochemical Studies of Disease-Associated Human Dicer Mutations on Processing of a Pre-microRNA and snoRNA.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00687
Abstract: Dicer is an RNase III enzyme that is responsible for the maturation of small RNAs such as microRNAs. As Dicer's cleavage products play key roles in promoting cellular homeostasis through the fine-tuning of gene expression,… read more here.
Keywords: platform paz; dicer; pre microrna; mutations processing ... See more keywords
Discovery of a Novel Small-Molecule Inhibitor Disrupting TRBP-Dicer Interaction against Hepatocellular Carcinoma via the Modulation of microRNA Biogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00189
Abstract: MicroRNAs (miRNAs) are key players in human hepatocellular carcinoma (HCC) tumorigenesis. Therefore, small molecules targeting components of miRNA biogenesis may provide new therapeutic means for HCC treatment. By a high-throughput screening and structural simplification, we… read more here.
Keywords: trbp dicer; dicer; hepatocellular carcinoma; small molecule ... See more keywords
RNA structure probing reveals the structural basis of Dicer binding and cleavage
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23607-w
Abstract: It is known that an RNA’s structure determines its biological function, yet current RNA structure probing methods only capture partial structure information. The ability to measure intact (i.e., full length) RNA structures will facilitate investigations… read more here.
Keywords: cleavage; structure probing; dicer; structure ... See more keywords
The importance of cellular and exosomal miRNAs in mesenchymal stem cell osteoblastic differentiation
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-85306-2
Abstract: The differentiation of osteoblasts is under complex regulation that includes autocrine and paracrine signaling from MSCs. Exosomes are important components of the MSC secretome and their cargo contains numerous miRNAs. In this study, the importance… read more here.
Keywords: hmscs; importance; osteoblastic differentiation; hmsc exosomes ... See more keywords