Small Molecule-Induced Dimerization of Hairpin RNA Interfered with the Dicer Cleavage Reaction.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00920
Abstract: MicroRNAs are potential targets for drug development. Small molecules that can inhibit or promote a specific miRNA's biogenesis would be useful for regulating its target genes. Various types of small molecules have been investigated so… read more here.
Keywords: dicer cleavage; cleavage reaction; hairpin rna;
ReCGBM: a gradient boosting-based method for predicting human dicer cleavage sites
Sign Up to like & getrecommendations! Published in 2021 at "BMC Bioinformatics"
DOI: 10.1186/s12859-021-03993-0
Abstract: Background Human dicer is an enzyme that cleaves pre-miRNAs into miRNAs. Several models have been developed to predict human dicer cleavage sites, including PHDCleav and LBSizeCleav. Given an input sequence, these models can predict whether… read more here.
Keywords: dicer cleavage; dicer; pre mirna; cleavage sites ... See more keywords
Predicting Drosha and Dicer Cleavage Sites with DeepMirCut
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.799056
Abstract: MicroRNAs are a class of small RNAs involved in post-transcriptional gene silencing with roles in disease and development. Many computational tools have been developed to identify novel microRNAs. However, there have been no attempts to… read more here.
Keywords: predicting drosha; cleavage sites; sequence; cleavage ... See more keywords