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Published in 2021 at "Biochemistry"
DOI: 10.1021/acs.biochem.0c00920
Abstract: MicroRNAs are potential targets for drug development. Small molecules that can inhibit or promote a specific miRNA's biogenesis would be useful for regulating its target genes. Various types of small molecules have been investigated so…
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Keywords:
dicer cleavage;
cleavage reaction;
hairpin rna;
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Published in 2021 at "BMC Bioinformatics"
DOI: 10.1186/s12859-021-03993-0
Abstract: Background Human dicer is an enzyme that cleaves pre-miRNAs into miRNAs. Several models have been developed to predict human dicer cleavage sites, including PHDCleav and LBSizeCleav. Given an input sequence, these models can predict whether…
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Keywords:
dicer cleavage;
dicer;
pre mirna;
cleavage sites ... See more keywords
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Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.799056
Abstract: MicroRNAs are a class of small RNAs involved in post-transcriptional gene silencing with roles in disease and development. Many computational tools have been developed to identify novel microRNAs. However, there have been no attempts to…
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Keywords:
predicting drosha;
cleavage sites;
sequence;
cleavage ... See more keywords