Thyroblastoma: A DICER1‐associated embryonal neoplasm and fine needle aspiration diagnostic criteria
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25105
Abstract: Thyroblastoma is a rare, aggressive embryonal thyroid neoplasm associated with DICER1 mutation. It usually presents as a rapidly growing thyroid mass diffusely infiltrating the thyroid lobes and extending into perithyroidal tissue. Most thyroblastomas were initially… read more here.
Keywords: thyroblastoma dicer1; dicer1 associated; neoplasm; fine needle ... See more keywords
NEUROECTODERMAL ELEMENTS ARE PART OF THE MORPHOLOGICAL SPECTRUM OF DICER1-ASSOCIATED NEOPLASMS.
Sign Up to like & getrecommendations! Published in 2022 at "Human pathology"
DOI: 10.1016/j.humpath.2022.02.018
Abstract: Many sarcomas with DICER1 pathogenic variants (PVs) exhibit a characteristic morphology, including a subepithelial layer of malignant mesenchymal cells, areas of rhabdomyoblastic differentiation and cartilaginous and/ or osseous elements. We report 5 DICER1-associated neoplasms (1… read more here.
Keywords: dicer1 associated; morphological spectrum; dicer1; part morphological ... See more keywords
Expanding the spectrum of dicer1-associated sarcomas
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DOI: 10.1038/s41379-019-0366-x
Abstract: DICER1 syndrome is a hereditary cancer predisposition syndrome caused by deleterious germline DICER1 mutations. Characteristic “hotspot” somatic mutations of DICER1 have been identified in DICER1-associated tumors. With the exception of genitourinary embryonal rhabdomyosarcoma and anaplastic… read more here.
Keywords: sarcoma; dicer1 associated; dicer1; associated sarcomas ... See more keywords
DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies
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DOI: 10.1158/1078-0432.ccr-17-3089
Abstract: Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome with a variety of manifestations. In addition to conferring increased cancer risks for pleuropulmonary blastoma (PPB) and ovarian sex cord–stromal tumors, particularly Sertoli–Leydig cell tumor,… read more here.
Keywords: dicer1 associated; risk; dicer1; associated conditions ... See more keywords