Improved lactate control with dichloroacetate in a case with severe neonatal lactic acidosis due to MTFMT mitochondrial translation disorder
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DOI: 10.1016/j.ymgmr.2020.100616
Abstract: Mitochondrial methionyl-tRNA formyltransferase (MTFMT) is a nuclear-encoded gene that produces a protein involved in mitochondrial translation. MTFMT formylates a portion of Met-tRNAMet, which allows for translation initiation of mitochondrial mRNA. Mutations in this gene have… read more here.
Keywords: lactic acidosis; lactate; dichloroacetate; translation ... See more keywords