Efficient synthesis of (S)-2-chloro-1-(2, 4-dichlorophenyl) ethanol using a tetrad mutant alcohol dehydrogenase from Lactobacillus kefir
Sign Up to like & getrecommendations! Published in 2019 at "Process Biochemistry"
DOI: 10.1016/j.procbio.2019.07.008
Abstract: Abstract As the key chiral intermediate of luliconazole, (S)-2-chloro-1-(2, 4-dichlorophenyl) ethanol ((S)-CPEO) was prepared from 2-chloro-1-(2, 4-dichlorophenyl) ethanone (CPE) using a tetrad mutant alcohol dehydrogenase (A94T/F147L/L199H/A202L) from Lactobacillus kefir (LK-TADH) coupled with glucose dehydrogenase (GDH).… read more here.
Keywords: chloro dichlorophenyl; dichlorophenyl; tetrad mutant; dehydrogenase ... See more keywords
Amino Alcohols as Potential Antibiotic and Antifungal Leads
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27072050
Abstract: Five focused compound libraries (forty-nine compounds), based on prior studies in our laboratory were synthesized and screened for antibiotic and anti-fungal activity against S. aureus, E. coli, K. pneumoniae, P. aeruginosa, A. baumannii, C. albicans… read more here.
Keywords: phenyl acrylonitrile; phenyl; dichlorophenyl hydroxy; propoxy phenyl ... See more keywords