Practical Synthesis of 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid—Key Intermediate of Lifitegrast (Xiidra)
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DOI: 10.1021/acsomega.3c02188
Abstract: In the present study, a practical method for synthesizing the key intermediate 5,7-dichlorotetrahydroisoquinoline-6-carboxylic acid (1) of Lifitegrast was proposed. First, an investigation was conducted into the utilization of the impurity and recrystallization method in the… read more here.
Keywords: dichlorotetrahydroisoquinoline; carboxylic acid; synthesis; lifitegrast ... See more keywords