Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03238-7
Abstract: Claudins are a family of integral tight junction proteins that regulate paracellular permeability in polarized epithelia. Overexpression or reduction of claudins can both promote and limit cancer progression, revealing complex dichotomous roles for claudins depending… read more here.
Keywords: knockout mice; cancer; roles claudins; dichotomous roles ... See more keywords
Dichotomous roles of co-stimulatory molecules in diabetes mellitus
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.23102
Abstract: Numerous studies have established the importance of immune dysfunction in the development of diabetes mellitus, including typ1 and typ2 diabetes, and it is worth noting that T cell activation acts a key role in the… read more here.
Keywords: stimulatory molecules; roles stimulatory; diabetes mellitus; dichotomous roles ... See more keywords
Dichotomous roles of IL-36 and IL-38 in cardiovascular disease
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2025.1642116
Abstract: Members of the interleukin-1 (IL-1) superfamily play crucial roles in orchestrating inflammation and immune responses. Among them, IL-36 and IL-38 have emerged as cytokines with contrasting roles in cardiovascular disease (CVD). IL-36 typically promotes inflammation,… read more here.
Keywords: cardiovascular disease; dichotomous roles; roles cardiovascular;
Glutathione Peroxidase GPX1 and Its Dichotomous Roles in Cancer
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DOI: 10.3390/cancers14102560
Abstract: Simple Summary Glutathione peroxidase 1 (GPX1), as one of the most important antioxidant enzymes, maintains cellular redox balance by regulating reactive oxygen species levels. In this review, we summarize and discuss the relationship between GPX1… read more here.
Keywords: dichotomous roles; glutathione peroxidase; gpx1; cancer ... See more keywords