Antisense mediated blockade of Dickkopf 1 attenuates tumor survival, metastases and bone damage in experimental osteosarcoma
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DOI: 10.1038/s41598-024-84037-4
Abstract: Osteosarcoma (OS) is the most common primary bone malignancy. The canonical Wnt inhibitor Dickkopf-1 (Dkk-1) has been implicated in bone destruction, tumor survival and metastases during OS. We examined the role of Dkk-1 in OS… read more here.
Keywords: survival; tumor survival; tumor; survival metastases ... See more keywords
Rationale for targeting the Wnt signalling modulator Dickkopf‐1 for oncology
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DOI: 10.1111/bph.13894
Abstract: Wnt signalling is a fundamental pathway involved in embryonic development and adult tissue homeostasis. Mutations in the pathway frequently lead to developmental defects and cancer. As such, therapeutic intervention of this pathway has generated tremendous… read more here.
Keywords: targeting wnt; rationale targeting; dickkopf; wnt signalling ... See more keywords
Effects of periodontal and bisphosphonate treatment on the gingival crevicular levels of sclerostin and dickkopf-1 in postmenopausal osteoporosis with and without periodontitis.
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DOI: 10.1111/jre.13023
Abstract: OBJECTIVE AND BACKGROUND Both periodontitis and osteoporosis are associated with osteoclast-related bone resorption. Bone metabolism is regulated by wingless-type MMTV integration site family (WNT), and WNT/β-catenin signals are controlled by physiological antagonists including dickkopf-1 (DKK-1)… read more here.
Keywords: dickkopf; sost; osteoporosis; group ... See more keywords
Differential Expression of Dickkopf 1 and Periostin in Mouse Strains with High and Low Bone Mass
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DOI: 10.3390/biology11121840
Abstract: Simple Summary Cells embedded in bone, so-called osteocytes, regulate bone metabolism by releasing various factors. Mouse studies are used both to investigate the background of various diseases and during the development of drugs. This is… read more here.
Keywords: periostin; dickkopf; bone; expression ... See more keywords