The immunomodulatory protein Dickkopf-1 (DKK1) defines a non-neuroendocrine subtype of metastatic castration-resistant prostate cancer (mCRPC) with low AR and low PSA expression.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.5054
Abstract: 5054Background: Advanced stagemCRPC can manifest AR-signaling independent growth typified by loss of AR and/or PSA expression in the absence of neuroendocrine (NE) features on biopsy. We sought to ... read more here.
Keywords: psa expression; psa; dickkopf dkk1; immunomodulatory protein ... See more keywords
Expression and Role of Dickkopf-1 (Dkk1) in Tumors: From the Cells to the Patients
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DOI: 10.2147/cmar.s275172
Abstract: Abstract Dickkopf-1 (Dkk1) is a secretory antagonist of the classical Wnt signaling pathway. Many studies have reported that Dkk1 is abnormally expressed in tumor cells, and abnormal expression of Dkk1 can inhibit cell proliferation or… read more here.
Keywords: expression; different tumors; tumor; dkk1 ... See more keywords