Tramadol/Diclofenac Fixed‐Dose Combination for Acute Pain Management: Bioavailability Assessment of a Generic Product
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DOI: 10.1002/cpdd.1410
Abstract: The multimodal analgesia strategy for acute pain involves using 2 or more analgesic medications with distinct mechanisms of action. This study assessed the bioavailability and tolerability of 2 tramadol hydrochloride (50 mg)/diclofenac sodium (50 mg)… read more here.
Keywords: tramadol; diclofenac; acute pain; dose combination ... See more keywords
Two Phase I, Randomized, Open‐Label, Multiple‐Dose, Crossover Studies Investigating the Systemic Bioavailability of Topical Diclofenac Diethylamine Gels Compared With Oral Diclofenac Tablets
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DOI: 10.1002/cpdd.1560
Abstract: Topical diclofenac diethylamine (DDEA) gels relieve pain while maintaining low diclofenac systemic concentrations in nontarget tissues. Characterizing diclofenac systemic exposure remains a mandated element in the development of topical diclofenac products. Two Phase I, randomized,… read more here.
Keywords: diclofenac; oral diclofenac; ddea gel; topical diclofenac ... See more keywords
Intestinal metabolism of diclofenac by polymorphic UGT2B17 correlates with its highly variable pharmacokinetics and safety across populations.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2907
Abstract: Although the United States and Europe have shifted to the prescription use of diclofenac due to several serious incidences of cardiotoxicity, it is one of the most commonly used over-the-counter (OTC) medicine in major parts… read more here.
Keywords: metabolism; intestinal metabolism; metabolism diclofenac; diclofenac polymorphic ... See more keywords
Comparison of efficacy of diclofenac and tramadol in relieving pain in patients of acute pancreatitis: A randomized parallel group double blind active controlled pilot study
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pain"
DOI: 10.1002/ejp.1515
Abstract: Opioids and non steroidal anti inflammatory drugs (NSAIDs) are commonly used for pain relief in acute pancreatitis (AP). Opioids carry risk of sphincter of oddi constriction. Although diclofenac prevents post endoscopic retrograde cholangio‐pancreatography (ERCP) pancreatitis,… read more here.
Keywords: acute pancreatitis; study; diclofenac; efficacy ... See more keywords
Inhibition of immune responses and related proteins in Rhamdia quelen exposed to diclofenac.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.3742
Abstract: Nonsteroidal anti-inflammatory drugs are among the most widely detected pharmaceuticals in surface water worldwide. The nonsteroidal anti-inflammatory drug diclofenac is used to treat many types of pain and inflammation. Diclofenac's potential to cause adverse effects… read more here.
Keywords: immune responses; diclofenac; responses related; inhibition immune ... See more keywords
Recovery from reproductive and morphological abnormalities in medaka (Oryzias latipes) following a 14-day exposure to diclofenac.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.3899
Abstract: Mating pairs of medaka (Oryzias latipes) were exposed to diclofenac at measured concentrations of 0 (control), 7.1, 37, and 78 μg/L for 14 d under static-renewal conditions. Effects on reproductive success, as well as morphological abnormalities,… read more here.
Keywords: oryzias latipes; morphological abnormalities; diclofenac; reproductive morphological ... See more keywords
Behaviour of diclofenac from contaminated fish after cooking and in-vitro digestion.
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DOI: 10.1002/jsfa.13430
Abstract: BACKGROUND Seafood consumers are widely exposed to diclofenac due to the high contamination levels often present in aquatic organisms. It is a potential risk to public health due its endocrine disruptor properties. Limited information is… read more here.
Keywords: vitro digestion; diclofenac; bioaccessibility; cooking ... See more keywords
Manganese Biochar Composites for Adsorptive Removal of Diclofenac From Wastewater
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DOI: 10.1002/tqem.70237
Abstract: Pharmaceuticals and personal care products released into wastewater have drawn widespread attention as emerging pollutants of concern in recent years owing to their potential risks to aquatic environments and human health. Diclofenac, a commonly used… read more here.
Keywords: diclofenac; adsorption; biochar composites; biochar ... See more keywords
Biotransformation of diclofenac by Stenotrophomonas humi strain DIC_5 and toxicological examination of the resulting metabolites
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DOI: 10.1007/s00253-024-13320-1
Abstract: The widely used non-steroidal anti-inflammatory drug, diclofenac, detected in increasing concentrations in freshwater ecosystems, is among the most pressing environmental problems today. In this study, the bacterial isolate Stenotrophomonas humi strain DIC_5 was capable of… read more here.
Keywords: stenotrophomonas humi; humi strain; diclofenac; biotransformation ... See more keywords
3D printed spinning cup-shaped device for immunoaffinity solid-phase extraction of diclofenac in wastewaters
Sign Up to like & getrecommendations! Published in 2022 at "Mikrochimica Acta"
DOI: 10.1007/s00604-022-05267-9
Abstract: This article reports current research efforts towards designing bespoke microscale extraction approaches exploiting the versatility of 3D printing for fast prototyping of novel geometries of sorptive devices. This is demonstrated via the so-called 3D printed… read more here.
Keywords: device; spinning cup; extraction; diclofenac ... See more keywords
Diclofenac sex-divergent drug-drug interaction with Sunitinib: pharmacokinetics and tissue distribution in male and female mice
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DOI: 10.1007/s10637-017-0447-y
Abstract: SummaryCoadministration of diclofenac and sunitinib, tyrosine kinase inhibitor, led to sex-divergent pharmacokinetic drug-drug interaction outcomes. Male and female mice were administered 60 mg/kg PO sunitinib alone (control groups) or with 30 mg/kg PO diclofenac. Sunitinib concentration in… read more here.
Keywords: sex divergent; male female; diclofenac; drug ... See more keywords