Intestinal metabolism of diclofenac by polymorphic UGT2B17 correlates with its highly variable pharmacokinetics and safety across populations.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2907
Abstract: Although the United States and Europe have shifted to the prescription use of diclofenac due to several serious incidences of cardiotoxicity, it is one of the most commonly used over-the-counter (OTC) medicine in major parts… read more here.
Keywords: metabolism; intestinal metabolism; metabolism diclofenac; diclofenac polymorphic ... See more keywords
Comparison of efficacy of diclofenac and tramadol in relieving pain in patients of acute pancreatitis: A randomized parallel group double blind active controlled pilot study
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pain"
DOI: 10.1002/ejp.1515
Abstract: Opioids and non steroidal anti inflammatory drugs (NSAIDs) are commonly used for pain relief in acute pancreatitis (AP). Opioids carry risk of sphincter of oddi constriction. Although diclofenac prevents post endoscopic retrograde cholangio‐pancreatography (ERCP) pancreatitis,… read more here.
Keywords: acute pancreatitis; study; diclofenac; efficacy ... See more keywords
Inhibition of immune responses and related proteins in Rhamdia quelen exposed to diclofenac.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.3742
Abstract: Nonsteroidal anti-inflammatory drugs are among the most widely detected pharmaceuticals in surface water worldwide. The nonsteroidal anti-inflammatory drug diclofenac is used to treat many types of pain and inflammation. Diclofenac's potential to cause adverse effects… read more here.
Keywords: immune responses; diclofenac; responses related; inhibition immune ... See more keywords
Recovery from reproductive and morphological abnormalities in medaka (Oryzias latipes) following a 14-day exposure to diclofenac.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.3899
Abstract: Mating pairs of medaka (Oryzias latipes) were exposed to diclofenac at measured concentrations of 0 (control), 7.1, 37, and 78 μg/L for 14 d under static-renewal conditions. Effects on reproductive success, as well as morphological abnormalities,… read more here.
Keywords: oryzias latipes; morphological abnormalities; diclofenac; reproductive morphological ... See more keywords
3D printed spinning cup-shaped device for immunoaffinity solid-phase extraction of diclofenac in wastewaters
Sign Up to like & getrecommendations! Published in 2022 at "Mikrochimica Acta"
DOI: 10.1007/s00604-022-05267-9
Abstract: This article reports current research efforts towards designing bespoke microscale extraction approaches exploiting the versatility of 3D printing for fast prototyping of novel geometries of sorptive devices. This is demonstrated via the so-called 3D printed… read more here.
Keywords: device; spinning cup; extraction; diclofenac ... See more keywords
Diclofenac sex-divergent drug-drug interaction with Sunitinib: pharmacokinetics and tissue distribution in male and female mice
Sign Up to like & getrecommendations! Published in 2017 at "Investigational New Drugs"
DOI: 10.1007/s10637-017-0447-y
Abstract: SummaryCoadministration of diclofenac and sunitinib, tyrosine kinase inhibitor, led to sex-divergent pharmacokinetic drug-drug interaction outcomes. Male and female mice were administered 60 mg/kg PO sunitinib alone (control groups) or with 30 mg/kg PO diclofenac. Sunitinib concentration in… read more here.
Keywords: sex divergent; male female; diclofenac; drug ... See more keywords
Aptamer-based sensor for diclofenac quantification using carbon nanotubes and graphene oxide decorated with magnetic nanomaterials
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-017-1259-x
Abstract: AbstractIn this contribution, a novel label-free electrochemical biosensor for diclofenac (DCF) detection was developed using the unique properties of acid-oxidized carbon nanotubes (CNT), graphene oxide (GO), and Fe3O4 magnetic nanomaterials. The GO sheets and CNT… read more here.
Keywords: graphene oxide; magnetic nanomaterials; detection; carbon nanotubes ... See more keywords
Poly(N-methacryloyl glycine)/nanocellulose composites as pH-sensitive systems for controlled release of diclofenac.
Sign Up to like & getrecommendations! Published in 2017 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2017.04.030
Abstract: The present study reports the development of non-cytotoxic and pH-sensitive nanostructured membranes consisting of a polymer with amino acid pending moieties and bacterial nanocellulose (BC). The nanocomposites were prepared through a simple methodology under green… read more here.
Keywords: glycine nanocellulose; controlled release; diclofenac; methacryloyl glycine ... See more keywords
Magnetic quaternary chitosan hybrid nanoparticles for the efficient uptake of diclofenac from water.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate polymers"
DOI: 10.1016/j.carbpol.2018.09.030
Abstract: The occurrence of pharmaceuticals in the environment and the water cycle, even at trace levels, has been a matter of great discussion in the literature in the recent years. Despite the clinical relevance of diclofenac… read more here.
Keywords: quaternary chitosan; water; diclofenac; chitosan hybrid ... See more keywords
Chronic exposure to diclofenac induces delayed mandibular defects in medaka (Oryzias latipes) in a sex-dependent manner.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.07.016
Abstract: Diclofenac is widely distributed in freshwater environments. To support a robust aquatic risk assessment, medaka (Oryzias latipes) were exposed to diclofenac at sublethal concentrations of 0.608, 2.15, 7.29, 26.5, and 94.8 μg/L (as mean measured concentrations)… read more here.
Keywords: oryzias latipes; sex dependent; diclofenac; medaka oryzias ... See more keywords
Photocatalytic-persulfate- oxidation for diclofenac removal from aqueous solutions: Modeling, optimization and biotoxicity test assessment.
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.129158
Abstract: In this paper, the influence of several aquatic factors (the nature of catalyst, the initial pH and the initial concentration of the pollutant) on the photocatalytic degradation of diclofenac (DFC), one of the most widely… read more here.
Keywords: degradation; removal; persulfate; diclofenac ... See more keywords