Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hepatology"
DOI: 10.1016/j.jhep.2020.09.019
Abstract: BACKGROUND Current antiviral therapies help keep hepatitis B virus (HBV) under control, but they are not curative. A cure for chronic hepatitis B (CHB) is lacking due to the inability of current therapies to eliminate… read more here.
Keywords: dicoumarol; hbv; hbx; cccdna transcription ... See more keywords
A pharmacological review of dicoumarol: an old natural anticoagulant agent.
Sign Up to like & getrecommendations! Published in 2020 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105193
Abstract: Dicoumarol is an oral anticoagulant agent prescribed in clinical for decades. It is a natural hydroxycoumarin discovered from the spoilage of Melilotus officinalis (L.) Pall and is originally discovered as a rodenticide. Due to its… read more here.
Keywords: dicoumarol; pharmacological review; anticoagulant agent; review dicoumarol ... See more keywords
Chitosan Catalyzed Novel Piperidinium Dicoumarol: Green Synthesis, X-ray Diffraction, Hirshfeld Surface and DFT Studies
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DOI: 10.3390/polym14091854
Abstract: The novel piperidinium dicoumarol has been synthesized by the reaction of 3-formylchromone, 4-hydroxycoumarin, and piperidine under chitosan catalyzed solvent-free green conditions. FT-IR and NMR spectroscopy established the structure of dicoumarol, which was further confirmed by… read more here.
Keywords: chitosan catalyzed; ray diffraction; piperidinium dicoumarol; dicoumarol ... See more keywords