Calcineurin Silencing in Dictyostelium discoideum Leads to Cellular Alterations Affecting Mitochondria, Gene Expression, and Oxidative Stress Response.
Sign Up to like & getrecommendations! Published in 2018 at "Protist"
DOI: 10.1016/j.protis.2018.04.004
Abstract: Calcineurin is involved in development and cell differentiation of the social amoeba Dictyostelium discoideum. However, since knockouts of the calcineurin-encoding genes are not possible in D. discoideum it is assumed that the phosphatase also plays… read more here.
Keywords: calcineurin; dictyostelium discoideum; cellular alterations; discoideum ... See more keywords
Confirmation and variability of the Allee effect in Dictyostelium discoideum cell populations, possible role of chemical signaling within cell clusters
Sign Up to like & getrecommendations! Published in 2021 at "Physical Biology"
DOI: 10.1088/1478-3975/ac4613
Abstract: In studies of the unicellular eukaryote Dictyostelium discoideum, many have anecdotally observed that cell dilution below a certain ‘threshold density’ causes cells to undergo a period of slow growth (lag). However, little is documented about… read more here.
Keywords: dictyostelium discoideum; growth; cell; variability ... See more keywords
Mapping and characterization of G-quadruplexes in the genome of the social amoeba Dictyostelium discoideum
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkz196
Abstract: Abstract G-quadruplexes (G4) are non-canonical DNA and/or RNA secondary structures formed in guanine-rich regions. Given their over-representation in specific regions in the genome such as promoters and telomeres, they are likely to play important roles… read more here.
Keywords: genome; dictyostelium; dictyostelium discoideum; social amoeba ... See more keywords
Microbe Profile: Dictyostelium discoideum: model system for development, chemotaxis and biomedical research.
Sign Up to like & getrecommendations! Published in 2021 at "Microbiology"
DOI: 10.1099/mic.0.001040
Abstract: The social amoeba Dictyostelium discoideum is a versatile organism that is unusual in alternating between single-celled and multi-celled forms. It possesses highly-developed systems for cell motility and chemotaxis, phagocytosis, and developmental pattern formation. As a… read more here.
Keywords: biomedical research; model; dictyostelium discoideum;
Spatial heterogeneities shape the collective behavior of signaling amoeboid cells
Sign Up to like & getrecommendations! Published in 2020 at "Science Signaling"
DOI: 10.1126/scisignal.aaz3975
Abstract: Imaging and mathematical analyses reveal how Dictyostelium discoideum cells navigate around obstacles in their environment. Slime mold obstacle course The slime mold Dictyostelium discoideum, which lives in the soil, is an experimental model of cell… read more here.
Keywords: cells spatial; slime mold; dictyostelium discoideum; spatial heterogeneities ... See more keywords
Studies of Streptococcus anginosus Virulence in Dictyostelium discoideum and Galleria mellonella Models
Sign Up to like & getrecommendations! Published in 2023 at "Infection and Immunity"
DOI: 10.1128/iai.00016-23
Abstract: For many years, Streptococcus anginosus has been considered a commensal colonizing the oral cavity, as well as the gastrointestinal and genitourinary tracts. However, recent epidemiological and clinical data designate this bacterium as an emerging opportunistic… read more here.
Keywords: infection; virulence; streptococcus anginosus; galleria mellonella ... See more keywords
An Autocrine Negative Feedback Loop Inhibits Dictyostelium discoideum Proliferation through Pathways Including IP3/Ca2+
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DOI: 10.1128/mbio.01347-21
Abstract: Many mammalian tissues such as the liver have the remarkable ability to regulate their size and have their cells stop proliferating when the tissue reaches the correct size. One possible mechanism involves the cells secreting… read more here.
Keywords: dictyostelium discoideum; polyphosphate; proliferation; stop proliferating ... See more keywords
A recombinant antibody toolbox for Dictyostelium discoideum
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DOI: 10.1186/s13104-020-05048-8
Abstract: The amoeba Dictyostelium discoideum has been a valuable model organism to study numerous facets of eukaryotic cell biology, such as cell motility, cell adhesion, macropinocytosis and phagocytosis, host–pathogen interactions and multicellular development. However, the relative… read more here.
Keywords: recombinant antibody; antibody toolbox; dictyostelium discoideum; toolbox dictyostelium ... See more keywords
Dictyostelium discoideum cells retain nutrients when the cells are about to outgrow their food source
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cell Science"
DOI: 10.1242/jcs.260107
Abstract: ABSTRACT Dictyostelium discoideum is a unicellular eukaryote that eats bacteria, and eventually outgrows the bacteria. D. discoideum cells accumulate extracellular polyphosphate (polyP), and the polyP concentration increases as the local cell density increases. At high… read more here.
Keywords: cell; discoideum cells; food; dictyostelium discoideum ... See more keywords
Endosomal vesicle fusion machinery is involved with the contractile vacuole in Dictyostelium discoideum.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.260477
Abstract: Contractile vacuoles (CVs) share common characteristics, such as a requirement for RAB11 and high levels of V-ATPase. These commonalities suggest a conserved evolutionary origin for the CVs with implications for understanding of the last common… read more here.
Keywords: endosomal vesicle; vesicle fusion; machinery; fusion machinery ... See more keywords
Generation of deletions and precise point mutations in Dictyostelium discoideum using the CRISPR nickase
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0224128
Abstract: The CRISPR/Cas9 system enables targeted genome modifications across a range of eukaryotes. Although we have reported that transient introduction of all-in-one vectors that express both Cas9 and sgRNAs can efficiently induce multiple gene knockouts in… read more here.
Keywords: point mutations; dictyostelium discoideum; precise point; discoideum ... See more keywords