Synthesis and In Vitro Pharmacological Evaluation of 5,8-Dideaza Analogs of Methotrexate
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DOI: 10.3390/molecules30132772
Abstract: This study describes the synthesis of a series of dideaza analogs of methotrexate and their preliminary pharmacological and metabolic evaluation. The 5,8-dideazamethotrexate was efficiently obtained in five steps using a new synthetic route. Oxygenated and… read more here.
Keywords: dideaza analogs; synthesis vitro; analogs methotrexate; vitro pharmacological ... See more keywords