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   Articles with "didymin" as a keyword



Didymin by suppressing NF-κB activation prevents VEGF-induced angiogenesis in vitro and in vivo.

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recommendations! Published in 2019 at "Vascular pharmacology"

DOI: 10.1016/j.vph.2019.01.002

Abstract: Although didymin, a dietary flavonoid glycoside from citrus fruits, known to be a potent antioxidant with anti-cancer activities, its role in angiogenesis is not known. In this study, we examined the effect of didymin on… read more here.

Keywords: vegf; vivo; didymin; induced angiogenesis ... See more keywords

Didymin Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cells by Modulating the PI3K/Akt Pathway

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recommendations! Published in 2025 at "Nutrition and Cancer"

DOI: 10.1080/01635581.2025.2454050

Abstract: Abstract Gastric cancer (GC) is a malignant tumor with high morbidity and mortality rates worldwide. This study aimed to investigate the effects and mechanisms of action of didymin, a dietary flavonoid glycoside, on GC treatment.… read more here.

Keywords: cancer; didymin; akt pathway; cell ... See more keywords

In vitro and in vivo evaluation of didymin cyclodextrin inclusion complexes: characterization and chemosensitization activity

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recommendations! Published in 2020 at "Drug Delivery"

DOI: 10.1080/10717544.2019.1704941

Abstract: Abstract Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics and combat… read more here.

Keywords: inclusion; didymin inclusion; didymin; didymin cyclodextrin ... See more keywords

Didymin Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the PPAR Signaling Pathway

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recommendations! Published in 2022 at "Yonsei Medical Journal"

DOI: 10.3349/ymj.2022.0040

Abstract: Purpose Cerebral ischemia-reperfusion (IR) injury is a severe secondary injury induced by reperfusion after stroke. Didymin has been reported to have a protective effect on intracerebral hemorrhage. However, the underlying mechanism of didymin on regulating… read more here.

Keywords: didymin; ppar; reperfusion; cerebral ischemia ... See more keywords

Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage

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recommendations! Published in 2022 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2022.810582

Abstract: Neuroinflammation has been proven to exert an important effect on brain injury after intracerebral hemorrhage (ICH). Previous studies reported that Didymin possessed anti-inflammatory properties after acute hepatic injury, hyperglycemia-induced endothelial dysfunction, and death. However, the… read more here.

Keywords: caspase; neuroinflammation; didymin; pyroptosis ... See more keywords