Didymin by suppressing NF-κB activation prevents VEGF-induced angiogenesis in vitro and in vivo.
Sign Up to like & getrecommendations! Published in 2019 at "Vascular pharmacology"
DOI: 10.1016/j.vph.2019.01.002
Abstract: Although didymin, a dietary flavonoid glycoside from citrus fruits, known to be a potent antioxidant with anti-cancer activities, its role in angiogenesis is not known. In this study, we examined the effect of didymin on… read more here.
Keywords: vegf; vivo; didymin; induced angiogenesis ... See more keywords
In vitro and in vivo evaluation of didymin cyclodextrin inclusion complexes: characterization and chemosensitization activity
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DOI: 10.1080/10717544.2019.1704941
Abstract: Abstract Didymin is a dietary flavonoid that first found in citrus fruits, and possesses antioxidant properties. Our preliminary experiments first discovered that didymin was able to sensitize the resistant cancer cells against chemotherapeutics and combat… read more here.
Keywords: inclusion; didymin inclusion; didymin; didymin cyclodextrin ... See more keywords
Didymin Alleviates Cerebral Ischemia-Reperfusion Injury by Activating the PPAR Signaling Pathway
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DOI: 10.3349/ymj.2022.0040
Abstract: Purpose Cerebral ischemia-reperfusion (IR) injury is a severe secondary injury induced by reperfusion after stroke. Didymin has been reported to have a protective effect on intracerebral hemorrhage. However, the underlying mechanism of didymin on regulating… read more here.
Keywords: didymin; ppar; reperfusion; cerebral ischemia ... See more keywords
Didymin Suppresses Microglia Pyroptosis and Neuroinflammation Through the Asc/Caspase-1/GSDMD Pathway Following Experimental Intracerebral Hemorrhage
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.810582
Abstract: Neuroinflammation has been proven to exert an important effect on brain injury after intracerebral hemorrhage (ICH). Previous studies reported that Didymin possessed anti-inflammatory properties after acute hepatic injury, hyperglycemia-induced endothelial dysfunction, and death. However, the… read more here.
Keywords: caspase; neuroinflammation; didymin; pyroptosis ... See more keywords